Počet záznamů: 1
Serine proteases in schistosomes and other trematodes
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SYSNO ASEP 0490315 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Serine proteases in schistosomes and other trematodes Tvůrce(i) Dvorak, J. (CZ)
Horn, Martin (UOCHB-X) RID, ORCIDZdroj.dok. International Journal for Parasitology. - : Elsevier - ISSN 0020-7519
Roč. 48, č. 5 (2018), s. 333-344Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. AU - Austrálie Klíč. slova proteolytic enzyme ; serine protease ; peptidase ; Trematoda ; Platyhelminthes ; Schistosoma ; fluke Vědní obor RIV CE - Biochemie Obor OECD Biochemistry and molecular biology CEP LD15101 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LO1302 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000430889100003 EID SCOPUS 85042653239 DOI 10.1016/j.ijpara.2018.01.001 Anotace Trematodes, also known as flukes, are phylogenetically ancient parasitic organisms. Due to their importance as human and veterinary parasites, their proteins have been investigated extensively as drug and vaccine targets. Among those, proteases, as crucial enzymes for parasite survival, are considered candidate molecules for anti-parasitic interventions. Surprisingly however, trematode serine proteases, in comparison with other groups of proteases, are largely neglected. Genes encoding serine proteases have been identified in trematode genomes in significant abundance, but the biological roles and biochemical functions of these proteases are poorly understood. However, increasing volumes of genomic and proteomic studies, and accumulated experimental evidence, indicate that this class of proteases plays a substantial role in host-parasite interactions and parasite survival. Here, we discuss in detail serine proteases at genomic and protein levels, and their known or hypothetical functions. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2019
Počet záznamů: 1