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Mannan-based conjugates as a multimodal imaging platform for lymph nodes
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SYSNO ASEP 0489337 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Mannan-based conjugates as a multimodal imaging platform for lymph nodes Tvůrce(i) Rabyk, Mariia (UMCH-V) RID, ORCID
Galisová, A. (CZ)
Jirátová, M. (CZ)
Patsula, Vitalii (UMCH-V) RID, ORCID
Srbová, Linda (UMCH-V)
Loukotová, Lenka (UMCH-V) RID, ORCID
Parnica, Jozef (UMCH-V)
Jirák, D. (CZ)
Štěpánek, Petr (UMCH-V) RID, ORCID
Hrubý, Martin (UMCH-V) RID, ORCIDZdroj.dok. Journal of Materials Chemistry B - ISSN 2050-750X
Roč. 6, č. 17 (2018), s. 2584-2596Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova polysaccharide modification ; mannan ; multimodal imaging Vědní obor RIV FR - Farmakologie a lékárnická chemie Obor OECD Pharmacology and pharmacy CEP NV15-25781A GA MZd - Ministerstvo zdravotnictví Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000431421800011 EID SCOPUS 85046642638 DOI 10.1039/C7TB02888A Anotace We show that mannan-based conjugates possess exceptional features for multimodal imaging because of their biocompatibility, biodegradability and self-targeting properties. Two new mannan conjugates, containing a gadolinium complex and a fluorescent probe, one based only on polysaccharide and the other one comprising polysaccharide with poly(2-methyl-2-oxazoline) grafts, were prepared and simultaneously visualized in vitro and in vivo by magnetic resonance and fluorescence imaging. The synthesis of these mannan-based complexes was based on alkylation with allyl bromide or grafting with poly(2-methyl-2-oxazoline) chains, followed by a thiol–ene click reaction with cysteamine to introduce primary amino groups into their structure. Finally, the obtained conjugates were functionalized with contrast labels using the corresponding N-hydroxysuccinimide esters. When used to detect lymph nodes, the polymers showed better imaging properties than a commercially available contrast agent. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2019
Počet záznamů: 1