Počet záznamů: 1
Comparative Metabolism of Free-living Bodo saltans and Parasitic Trypanosomatids
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SYSNO ASEP 0469001 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Comparative Metabolism of Free-living Bodo saltans and Parasitic Trypanosomatids Tvůrce(i) Opperdoes, F. R. (BE)
Butenko, A. (CZ)
Flegontov, P. (CZ)
Yurchenko, V. (CZ)
Lukeš, Julius (BC-A) RID, ORCIDCelkový počet autorů 5 Zdroj.dok. Journal of Eukaryotic Microbiology. - : Wiley - ISSN 1066-5234
Roč. 63, č. 5 (2016), s. 657-678Poč.str. 22 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova adaptation ; Leishmania ; Leptomonas ; lateral gene transfer ; parasitism ; Phytomonas ; Trypanosoma Vědní obor RIV EB - Genetika a molekulární biologie CEP GA14-23986S GA ČR - Grantová agentura ČR Institucionální podpora BC-A - RVO:60077344 UT WOS 000382492500014 EID SCOPUS 84985993351 DOI 10.1111/jeu.12315 Anotace Comparison of the genomes of free-living Bodo saltans and those of parasitic trypanosomatids reveals that the transition from a free-living to a parasitic life style has resulted in the loss of approximately 50% of protein-coding genes. Despite this dramatic reduction in genome size, B. saltans and trypanosomatids still share a significant number of common metabolic traits: glycosomes; a unique set of the pyrimidine biosynthetic pathway genes; an ATP-PFK which is homologous to the bacterial PPi-PFKs rather than to the canonical eukaryotic ATP-PFKs; an alternative oxidase; three phosphoglycerate kinases and two GAPDH isoenzymes; a pyruvate kinase regulated by fructose-2,6-bisphosphate; trypanothione as a substitute for glutathione; synthesis of fatty acids via a unique set of elongase enzymes; and a mitochondrial acetate: succinate coenzyme A transferase. B. saltans has lost the capacity to synthesize ubiquinone. Among genes that are present in B. saltans and lost in all trypanosomatids are those involved in the degradation of mureine, tryptophan and lysine. Novel acquisitions of trypanosomatids are components of pentose sugar metabolism, pteridine reductase and bromodomain-factor proteins. In addition, only the subfamily Leishmaniinae has acquired a gene for catalase and the capacity to convert diaminopimelic acid to lysine. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2017
Počet záznamů: 1