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Antifouling polymer brushes displaying antithrombogenic surface properties
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SYSNO ASEP 0458015 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Antifouling polymer brushes displaying antithrombogenic surface properties Tvůrce(i) de los Santos Pereira, Andres (UMCH-V) RID, ORCID
Sheikh, S. (CA)
Blaszykowski, C. (CA)
Pop-Georgievski, Ognen (UMCH-V) RID, ORCID
Fedorov, K. (CA)
Thompson, M. (CA)
Rodriguez-Emmenegger, Cesar (UMCH-V) RIDZdroj.dok. Biomacromolecules. - : American Chemical Society - ISSN 1525-7797
Roč. 17, č. 3 (2016), s. 1179-1185Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova polymer brushes ; surface characterization ; antifouling surfaces Vědní obor RIV BO - Biofyzika CEP GJ15-09368Y GA ČR - Grantová agentura ČR ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000372391800051 EID SCOPUS 84960877090 DOI 10.1021/acs.biomac.6b00019 Anotace The contact of blood with artificial materials generally leads to immediate protein adsorption (fouling), which mediates subsequent biological processes such as platelet adhesion and activation leading to thrombosis. Recent progress in the preparation of surfaces able to prevent protein fouling offers a potential avenue to mitigate this undesirable effect. In the present contribution, we have prepared several types of state-of-the-art antifouling polymer brushes on polycarbonate plastic substrate, and investigated their ability to prevent platelet adhesion and thrombus formation under dynamic flow conditions using human blood. Moreover, we compared the ability of such brushes-grafted on quartz via an adlayer analogous to that used on polycarbonate-to prevent protein adsorption from human blood plasma, assessed for the first time by means of an ultrahigh frequency acoustic wave sensor. Results show that the prevention of such a phenomenon constitutes one promising route toward enhanced resistance to thrombus formation, and suggest that antifouling polymer brushes could be of service in biomedical applications requiring extensive blood-material surface contact. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2017
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