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Lipid-Based Diets Improve Muscarinic Neurotransmission in the Hippocampus of Transgenic APPswe/PS1dE9 Mice
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SYSNO ASEP 0454411 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Lipid-Based Diets Improve Muscarinic Neurotransmission in the Hippocampus of Transgenic APPswe/PS1dE9 Mice Tvůrce(i) Janíčková, Helena (FGU-C) RID, ORCID, SAI
Rudajev, Vladimír (FGU-C) RID
Dolejší, Eva (FGU-C) RID, ORCID
Koivisto, H. (FI)
Jakubík, Jan (FGU-C) RID, ORCID
Tanila, H. (FI)
El-Fakahany, E. E. (US)
Doležal, Vladimír (FGU-C) RID, ORCIDZdroj.dok. Current Alzheimer Research. - : Bentham Science Publishers - ISSN 1567-2050
Roč. 12, č. 10 (2015), s. 923-931Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova G-protein activation ; hippocampus ; muscarinic neurotransmission ; nutrition ; omega-3 fatty acids ; stigmasterol Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy CEP 7E10060 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy EE2.3.30.0025 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora FGU-C - RVO:67985823 UT WOS 000366135300002 EID SCOPUS 84959563947 DOI 10.2174/1567205012666151027130350 Anotace Transgenic APPswe/PS1dE9 mice modeling Alzheimer's disease demonstrate ongoing accumulation of beta-amyloid fragments resulting in formation of amyloid plaques that starts at the age of 4-5 months. Buildup of beta-amyloid fragments is accompanied by impairment of muscarinic transmission that becomes detectable at this age, well before the appearance of cognitive deficits that manifest around the age of 12 months. We have recently demonstrated that long-term feeding of trangenic mice with specific isocaloric fish oil-based diets improves specific behavioral parameters. Now we report on the influence of short-term feeding (3 weeks) of three isocaloric diets supplemented with Fortasyn (containing fish oil and ingredients supporting membrane renewal), the plant sterol stigmasterol together with fish oil, and stigmasterol alone on markers of cholinergic neurotransmission in the hippocampus of 5-month-old transgenic mice and their wild-type littermates. Our data demonstrate that even short-term feeding of transgenic mice with chow containing specific lipid-based dietary supplements can influence markers of cholinergic synapses and rectify impaired muscarinic signal transduction that develops in transgenic mice Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2016
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