Počet záznamů: 1
Traceless bioresponsive shielding of adenovirus hexon with HPMA copolymers maintains transduction capacity in vitro and in vivo
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SYSNO ASEP 0425747 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Traceless bioresponsive shielding of adenovirus hexon with HPMA copolymers maintains transduction capacity in vitro and in vivo Tvůrce(i) Prill, J.-M. (DE)
Šubr, Vladimír (UMCH-V) RID, ORCID
Pasquarelli, N. (DE)
Engler, T. (DE)
Hoffmeister, A. (DE)
Kochanek, S. (DE)
Ulbrich, Karel (UMCH-V) RID
Kreppel, F. (DE)Zdroj.dok. PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 9, č. 1 (2014), e82716_1-e82716_15Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova adenovirus ; HPMA copolymers ; bioresponsive shielding Vědní obor RIV CD - Makromolekulární chemie Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000330507300010 EID SCOPUS 84900312370 DOI 10.1371/journal.pone.0082716 Anotace Capsid surface shielding of adenovirus vectors with synthetic polymers is an emerging technology to reduce unwanted interactions of the vector particles with cellular and non-cellular host components. While it has been shown that attachment of shielding polymers allows prevention of undesired interactions, it has become evident that a shield which is covalently attached to the vector surface can negatively affect gene transfer efficiency. Reasons are not only a limited receptor-binding ability of the shielded vectors but also a disturbance of intracellular trafficking processes, the latter depending on the interaction of the vector surface with the cellular transport machinery. A solution might be the development of bioresponsive shields that are stably maintained outside the host cell but released upon cell entry to allow for efficient gene delivery to the nucleus. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2014
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