Počet záznamů: 1
Role of HIF1 Pathways in Diabetic Embryopathy
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SYSNO ASEP 0355314 Druh ASEP C - Konferenční příspěvek (mezinárodní konf.) Zařazení RIV Záznam nebyl označen do RIV Název Role of HIF1 Pathways in Diabetic Embryopathy Tvůrce(i) Pavlínková, Gabriela (BTO-N) RID, ORCID
Kappen, C. (US)
Bohuslavová, Romana (BTO-N) RID
Salbaum, J.M. (US)Zdroj.dok. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY. - : Wiley-Blackwell, 2009 - ISSN 1542-0752 Rozsah stran s. 413-413 Poč.str. 1 s. Akce Platform presentation at 49th Annual Meeting of the Teratology Society Datum konání 27.06.2009-01.07.2009 Místo konání Puerto Rico Země CR - Kostarika Typ akce WRD Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova diabetic embryopathy Vědní obor RIV FB - Endokrinologie, diabetologie, metabolizmus, výživa CEZ AV0Z50520701 - BTO-N (2007-2013) Anotace Diabetes represents a major complication for pregnancy because it increases the risk for congenital abnormalities in humans. Diabetic embryopathy can affect any developing organ system, although cardiovascular malformations and neural tube defects are the most prominent congenital malformations associated with diabetic pregnancy.Although the development of congenital malformations associated with maternal diabetes is well recognized, it is not well understood. Using the mouse as an experimental system and gene expression profiling, we have identified genes whose expression is significantly changed in embryos exposed to maternal diabetes. A substantial fraction of these genes is known to be essential for normal embryonic development and metabolism. Interestingly, the largest number of genes (25/146) was in the transcriptional factor functional category.We hypothesize that the metabolic imbalance occurring in diabetic pregnancy alters transcriptional regulation in the developing embryo Pracoviště Biotechnologický ústav Kontakt Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Rok sběru 2011
Počet záznamů: 1