Accumulation of 210 kDa microtubule-interacting protein in differentiating P19 embryonal carcinoma cells

0190933 - UMG-J 20000029 RIV NL eng J - Článek v odborném periodiku
Zíková, Martina - Sulimenko, Vadym - Dráber, Pavel - Dráberová, Eduarda
Accumulation of 210 kDa microtubule-interacting protein in differentiating P19 embryonal carcinoma cells.
FEBS Letters. Roč. 473, č. 1 (2000), s. 19-23. ISSN 0014-5793. E-ISSN 1873-3468
Grant CEP: GA ČR GV312/96/K205; GA ČR GA204/98/1054; GA AV ČR KSK2038602
Výzkumný záměr: CEZ:AV0Z5052915
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 3.440, rok: 2000

Expression of the MA-01 antigen, a thermolabile 210 kDa microtubule-interacting protein, was analysed during neuronal differentiation of P19 embryonal carcinoma cells. The level of MA-01 expression increased approximately ten times during 15 days. The increase started after 2 days of incubation with retinoaic acid and preceded the appearance of neuron-specific tubulin betaIII and neurofilaments. These data indicate that enhanced expression of MA-01 antigen is one of the earliest events occurring in P19 cells during neuronal differentiation.
Trvalý link: http://hdl.handle.net/11104/0086695