Počet záznamů: 1
Chromosome Division in Early Embryos-Is Everything under Control? And Is the Cell Size Important?
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SYSNO ASEP 0584104 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Chromosome Division in Early Embryos-Is Everything under Control? And Is the Cell Size Important? Tvůrce(i) Horáková, Adéla (UZFG-Y)
Konečná, Markéta (UZFG-Y)
Anger, Martin (UZFG-Y) ORCIDCelkový počet autorů 3 Číslo článku 2101 Zdroj.dok. International Journal of Molecular Sciences. - : MDPI - ISSN 1661-6596
Roč. 25, č. 4 (2024)Poč.str. 14 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova spindle ; chromosome division ; segregation errors ; spindle assembly checkpoint ; embryo ; cdk1 ; cell size ; aneuploidy Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Cell biology CEP GA19-24528S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UZFG-Y - RVO:67985904 UT WOS 001172049100001 EID SCOPUS 85185954676 DOI 10.3390/ijms25042101 Anotace Chromosome segregation in female germ cells and early embryonic blastomeres is known to be highly prone to errors. The resulting aneuploidy is therefore the most frequent cause of termination of early development and embryo loss in mammals. And in specific cases, when the aneuploidy is actually compatible with embryonic and fetal development, it leads to severe developmental disorders. The main surveillance mechanism, which is essential for the fidelity of chromosome segregation, is the Spindle Assembly Checkpoint (SAC). And although all eukaryotic cells carry genes required for SAC, it is not clear whether this pathway is active in all cell types, including blastomeres of early embryos. In this review, we will summarize and discuss the recent progress in our understanding of the mechanisms controlling chromosome segregation and how they might work in embryos and mammalian embryos in particular. Our conclusion from the current literature is that the early mammalian embryos show limited capabilities to react to chromosome segregation defects, which might, at least partially, explain the widespread problem of aneuploidy during the early development in mammals. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2025 Elektronická adresa https://www.mdpi.com/1422-0067/25/4/2101
Počet záznamů: 1