Počet záznamů: 1
An analogue of the Prolactin Releasing Peptide reduces obesity and promotes adult neurogenesis.
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SYSNO ASEP 0583336 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název An analogue of the Prolactin Releasing Peptide reduces obesity and promotes adult neurogenesis. Tvůrce(i) Jörgensen, S. K. M. (GB)
Karnošová, Alena (UOCHB-X)
Mazzaferro, S. (GB)
Rowley, O. (GB)
Chen, H. J. C. (GB)
Robbins, S. J. (GB)
Christofides, S. (GB)
Merkle, F. T. (GB)
Maletínská, Lenka (UOCHB-X) RID, ORCID
Petrik, D. (GB)Zdroj.dok. Embo Reports - ISSN 1469-221X
Roč. 25, č. 1 (2024), s. 351-377Poč.str. 27 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova adult neurogenesis ; anti-obesity peptides ; hypothalamus ; neural stem cells ; prolactin releasing peptide Způsob publikování Open access Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 001204737100020 EID SCOPUS 85183333411 DOI 10.1038/s44319-023-00016-2 Anotace Hypothalamic Adult Neurogenesis (hAN) has been implicated in regulating energy homeostasis. Adult-generated neurons and adult Neural Stem Cells (aNSCs) in the hypothalamus control food intake and body weight. Conversely, diet-induced obesity (DIO) by high fat diets (HFD) exerts adverse influence on hAN. However, the effects of anti-obesity compounds on hAN are not known. To address this, we administered a lipidized analogue of an anti-obesity neuropeptide, Prolactin Releasing Peptide (PrRP), so-called LiPR, to mice. In the HFD context, LiPR rescued the survival of adult-born hypothalamic neurons and increased the number of aNSCs by reducing their activation. LiPR also rescued the reduction of immature hippocampal neurons and modulated calcium dynamics in iPSC-derived human neurons. In addition, some of these neurogenic effects were exerted by another anti-obesity compound, Liraglutide. These results show for the first time that anti-obesity neuropeptides influence adult neurogenesis and suggest that the neurogenic process can serve as a target of anti-obesity pharmacotherapy. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2025 Elektronická adresa https://doi.org/10.1038/s44319-023-00016-2
Počet záznamů: 1