Počet záznamů: 1
Transcriptomic alterations in the olfactory bulb induced by exposure to air pollution: Identification of potential biomarkers and insights into olfactory system function
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SYSNO ASEP 0582006 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Transcriptomic alterations in the olfactory bulb induced by exposure to air pollution: Identification of potential biomarkers and insights into olfactory system function Tvůrce(i) Saveleva, L. (FI)
Šíma, Michal (UEM-P) RID, ORCID
Kléma, J. (CZ)
Krejčík, Zdeněk (UEM-P)
Vartiainen, N. (FI)
Sitnikova, V. (FI)
Belaya, I. (FI)
Malm, T. (FI)
Jalava, P.I. (FI)
Rössner st., Pavel (UEM-P)
Kanninen, K. M. (FI)Číslo článku 104316 Zdroj.dok. Environmental Toxicology and Pharmacology. - : Elsevier - ISSN 1382-6689
Roč. 104, nov. (2023)Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova air pollution ; ultrafine particles (UFP) ; brain ; olfactory bulb ; odorant-binding protein (OBP) ; myelin protein zero (Mpz) Obor OECD Public and environmental health CEP LM2018124 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LM2018133 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy EF16_013/0001821 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UEM-P - RVO:68378041 UT WOS 001125761000001 EID SCOPUS 85178282416 DOI 10.1016/j.etap.2023.104316 Anotace This study evaluated how exposure to the ubiquitous air pollution component, ultrafine particles (UFPs), alters the olfactory bulb (OB) transcriptome. The study utilised a whole-body inhalation chamber to simulate real-life conditions and focused on UFPs due to their high translocation and deposition ability in OBs as well as their prevalence in ambient air. Female C57BL/6J mice were exposed to clean air or to freshly generated combustion derived UFPs for two weeks, after which OBs were dissected and mRNA transcripts were investigated using RNA sequencing analysis. For the first time, transcriptomics was applied to determine changes in mRNA expression levels occurring after subacute exposure to UFPs in the OBs. We found forty-five newly described mRNAs to be involved in air pollution-induced responses, including genes involved in odorant binding, synaptic regulation, and myelination signalling pathway, providing new gene candidates for future research. This study provides new insights for the environmental science and neuroscience fields and nominates future research directions. Pracoviště Ústav experimentální medicíny Kontakt Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Rok sběru 2024 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S1382668923002582?via%3Dihub
Počet záznamů: 1