Počet záznamů: 1
Chronic Inflammation Promotes Cancer Progression as a Second hit.
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SYSNO ASEP 0578355 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Chronic Inflammation Promotes Cancer Progression as a Second hit. Tvůrce(i) Burocziová, Monika (UMG-J)
Grušanovič, Srdjan (UMG-J)
Vaníčková, Karolína (UMG-J)
Kosanovič, Slaďana (UMG-J)
Alberich-Jorda, Meritxell (UMG-J) RIDCelkový počet autorů 5 Zdroj.dok. Experimental Hematology. - : Elsevier - ISSN 0301-472X
Roč. 128, Dec 23 (2023), s. 30-37Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova CMO mice ; cancer progression ; Acute myeloid leukemia (AML) Obor OECD Biochemistry and molecular biology CEP GA20-03380S GA ČR - Grantová agentura ČR LX22NPO5102 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UMG-J - RVO:68378050 UT WOS 001130092800001 EID SCOPUS 85172769299 DOI 10.1016/j.exphem.2023.09.002 Anotace Acute myeloid leukemia (AML) is a malignant neoplasia of the hematopoietic system characterized by the accumulation of immature and nonfunctional leukemic blasts in the bone marrow and peripheral tissues. Mechanistically, the development of AML is explained by the .two-hit. theory, which is based on the accumulation of driver mutations that will cooperate to induce transformation. However, a significant percentage of patients with AML exhibit only one driver mutation, and thus, how leukemic transformation occurs in these cases is unclear. Accumulating evidence suggests that nongenetic factors, such as chronic inflammation, might influence AML development, and accordingly, clinical data have reported that patients with chronic inflammatory disorders have an increased risk of developing hematological malignancies. Here, using a mouse model of chronic inflammation, we demonstrate that systemic elevated levels of cytokines and chemokines and hyperactivation of the Jak/Stat3 signaling pathway may substitute .second hit. mutations and accelerate tumorigenesis. Altogether, our data highlight chronic inflammation as an additional factor in the development of AML, providing additional understanding of the mechanisms of transformation and opening new avenues for the treatment of this disease. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2024 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S0301472X23017022?via%3Dihub
Počet záznamů: 1