Počet záznamů: 1
Voltammetric analysis of mephenoxalone drug in pharmaceutical and biological samples using novel screen-printed sensor with boron-doped diamond electrode
- 1.
SYSNO ASEP 0576141 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Voltammetric analysis of mephenoxalone drug in pharmaceutical and biological samples using novel screen-printed sensor with boron-doped diamond electrode Tvůrce(i) Matvieiev, O. (CZ)
Šelešovská, R. (CZ)
Sokolová, Romana (UFCH-W) RID, ORCID, SAI
Jerga, R. (CZ)
Skopalová, J. (CZ)
Barták, P. (CZ)
Chýlková, J. (CZ)
Vojs, M. (SK)Číslo článku 134700 Zdroj.dok. Sensors and Actuators B - Chemical. - : Elsevier
Roč. 397, DEC 2023 (2023)Poč.str. 10 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova mephenoxalone ; voltammetry ; spectroelectrochemistry Vědní obor RIV CG - Elektrochemie Obor OECD Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis) CEP GA20-01589S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UFCH-W - RVO:61388955 UT WOS 001165280100001 EID SCOPUS 85173127132 DOI 10.1016/j.snb.2023.134700 Anotace A novel screen-printed sensor (SPE) with boron-doped diamond electrode (BDDE) for determination of a muscle relaxant and mild anxiolytic mephenoxalone (MNL) was developed. The sensor utilizes the electrochemical oxidation of MNL, which was firstly studied in aqueous solution using oxygen terminated BDDE. MNL provided an irreversible anodic signal at a potential of + 1380 mV (vs. Ag/AgCl/KCl sat.) over a wide pH range. Britton-Robinson buffer (pH 9) was selected as a suitable electrolyte and the square-wave voltammetric method (SWV) was developed. The low detection limit (55 nmol L–1), wide linear dynamic range (0.1–30 µmol L−1), and good recovery in the analysis of model and pharmaceutical samples (RSD < 1.77%) were attained. Subsequently, the new method was successfully transferred to SPE, which can find application in point-of-care testing. These sensors proved excellent sensitivity and reproducibility in the analysis of biological samples (RSD < 4.94%) without pretreatment and no need of electrolyte. Based on gas chromatography with mass spectrometry (GC-MS) analysis of preparative electrolysis products, a mechanism of the electrochemical oxidation of MNL was proposed, describing the oxidative cleavage of the alkoxybenzene ring. These results were supported with HOMO spatial distribution calculations and atomic charges calculations for arising radical cations, and with spectroelectrochemical measurements. Pracoviště Ústav fyzikální chemie J.Heyrovského Kontakt Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Rok sběru 2024 Elektronická adresa https://hdl.handle.net/11104/0345733
Počet záznamů: 1