Počet záznamů: 1
Spatial-Temporal Genome Regulation in Stress-Response and Cell-Fate Change
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SYSNO ASEP 0570211 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Spatial-Temporal Genome Regulation in Stress-Response and Cell-Fate Change Tvůrce(i) Erenpreisa, J. (LV)
Giuliani, A. (IT)
Yoshikawa, K. (JP)
Falk, Martin (BFU-R) RID, ORCID
Hildenbrand, G. (DE)
Salmina, K. (LV)
Freivalds, T. (LB)
Vainshelbaum, N. (LT)
Weidner, J. (DE)
Sievers, A. (DE)
Pilarczyk, G. (DE)
Hausmann, M. (DE)Celkový počet autorů 12 Číslo článku 2658 Zdroj.dok. International Journal of Molecular Sciences. - : MDPI
Roč. 24, č. 3 (2023)Poč.str. 40 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova dynamic genome organization ; epigenetic interactions ; heterochromatin and self-organization ; organizational and functional networks ; gene activity oscillations ; transposon-effected regulation ; fluorescence microscopy Vědní obor RIV CE - Biochemie Obor OECD Biochemistry and molecular biology CEP GC20-04109J GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora BFU-R - RVO:68081707 UT WOS 000935710200001 EID SCOPUS 85147892633 DOI 10.3390/ijms24032658 Anotace Complex functioning of the genome in the cell nucleus is controlled at different levels: (a) the DNA base sequence containing all relevant inherited information, (b) epigenetic pathways consisting of protein interactions and feedback loops, (c) the genome architecture and organization activating or suppressing genetic interactions between different parts of the genome. Most research so far has shed light on the puzzle pieces at these levels. This article, however, attempts an integrative approach to genome expression regulation incorporating these different layers. Under environmental stress or during cell development, differentiation towards specialized cell types, or to dysfunctional tumor, the cell nucleus seems to react as a whole through coordinated changes at all levels of control. This implies the need for a framework in which biological, chemical, and physical manifestations can serve as a basis for a coherent theory of gene self-organization. An international symposium held at the Biomedical Research and Study Center in Riga, Latvia, on 25 July 2022 addressed novel aspects of the abovementioned topic. The present article reviews the most recent results and conclusions of the state-of-the-art research in this multidisciplinary field of science, which were delivered and discussed by scholars at the Riga symposium. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2024 Elektronická adresa https://www.mdpi.com/1422-0067/24/3/2658
Počet záznamů: 1