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pH-Dependent disruption of giant polymer vesicles: a step towards biomimetic membranes
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SYSNO ASEP 0567447 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název pH-Dependent disruption of giant polymer vesicles: a step towards biomimetic membranes Tvůrce(i) Sincari, Vladimir (UMCH-V) ORCID, RID
Jäger, Eliezer (UMCH-V) ORCID, RID
Loureiro, Kahynna Cavalcante (UMCH-V)
Vragović, Martina (UMCH-V)
Hofmann, E. (DE)
Schlenk, M. (DE)
Filipová, Marcela (UMCH-V) RID, ORCID
Rydvalová, Eliška (UMCH-V) ORCID
Štěpánek, Petr (UMCH-V) RID, ORCID
Hrubý, Martin (UMCH-V) RID, ORCID
Förster, S. (DE)
Jäger, Alessandro (UMCH-V) RID, ORCIDZdroj.dok. Polymer Chemistry . - : Royal Society of Chemistry - ISSN 1759-9954
Roč. 14, č. 4 (2023), s. 443-451Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova polymer ; vesicles ; giant Obor OECD Polymer science CEP GJ20-13946Y GA ČR - Grantová agentura ČR GJ20-15077Y GA ČR - Grantová agentura ČR GA21-04166S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000899359800001 EID SCOPUS 85144786973 DOI 10.1039/D2PY01229D Anotace Giant unilamellar polymer vesicles (GUPVs) capable of selectively delivering protected payloads into intracellular environments and releasing them in stimuli-triggered, precise spatially and temporally controlled manners are attractive bioactive cargo delivery tools. Herein, we present highly size-defined and monodisperse (42.1 ± 1.2, 60.5 ± 1.0, 80.4 ± 1.4 and 97.9 ± 1.2 μm in diameter, respectively) pH-responsive giant GUPVs prepared via microfluidic droplet generation using a flow-focusing poly(dimethylsiloxane) (PDMS)-based microfluidic device. Poly(ethylene oxide)-block-poly[2-(diisopropylamino)ethyl methacrylate] (PEO-b-PDPA) is a pH-responsive polymer that was synthesized via reversible addition–fragmentation chain-transfer (RAFT) polymerization and used in combination with poly(ethylene oxide)-block-poly(1,2-butadiene) (PEO-b-PBD) to produce homogeneous pH-responsive giant GUPVs. To demonstrate the spatiotemporal control provided by this approach, we studied in detail the pH-responsiveness of GUPVs according to the disruption and release of dye cargo under distinct acidic conditions using fluorescence confocal microscopy. This approach can be utilized to fabricate pH-responsive delivery systems for various active compounds, microreactors, and artificial organelles, thereby paving the way towards cell mimicry.
Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2024 Elektronická adresa https://pubs.rsc.org/en/content/articlelanding/2023/PY/D2PY01229D
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