Treatment of phenylalanine and tyrosine in phosphate-buffered saline by plasma-supplied oxygen atoms: Chemical characterization and bactericidal effects

0567035 - ÚFP 2023 RIV DE eng J - Článek v odborném periodiku
Jirásek, Vít - Tarabová, Barbora - Lukeš, Petr
Treatment of phenylalanine and tyrosine in phosphate-buffered saline by plasma-supplied oxygen atoms: Chemical characterization and bactericidal effects.
Plasma Processes and Polymers. Roč. 19, č. 11 (2022), č. článku 2200079. ISSN 1612-8850. E-ISSN 1612-8869
Grant CEP: GA ČR(CZ) GA19-25026S
Institucionální podpora: RVO:61389021
Klíčová slova: amino acids * chlorination * nonthermal plasma * oxidation * plasma jet
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 3.5, rok: 2022
Způsob publikování: Omezený přístup
https://onlinelibrary.wiley.com/doi/10.1002/ppap.202200079

Plasma-treated liquid media containing amino acids have been shown to be effective as disinfectants and antitumor agents. The current study presents chemical analyses and bactericidal properties of mixtures formed by the treatment of phenylalanine and tyrosine in phosphate-buffered saline in He/O2 plasma. A major process observed was the formation of amino acid mono- and di-chloramines accompanied by the oxidation of the amino acid aromatic ring. The chemical activity of treated solutions lasted up to 90 min after plasma treatment. After being acidified to ~pH 3, the treated solutions exhibited a bactericidal effect against Escherichia coli. This effect was associated with the post-discharge reactions of amino acid dichloramines and the formation of C-1 nitrile as the final product.
Trvalý link: https://hdl.handle.net/11104/0338301