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Microwave irradiation-assisted reversible addition-fragmentation chain transfer polymerization-induced self-assembly of pH-responsive diblock copolymer nanoparticles
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SYSNO ASEP 0564924 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Microwave irradiation-assisted reversible addition-fragmentation chain transfer polymerization-induced self-assembly of pH-responsive diblock copolymer nanoparticles Tvůrce(i) Lukáš Petrova, Svetlana (UMCH-V) ORCID, RID
Sincari, Vladimir (UMCH-V) ORCID, RID
Konefal, Rafal (UMCH-V) RID, ORCID
Pavlova, Ewa (UMCH-V) RID
Hrubý, Martin (UMCH-V) RID, ORCID
Pokorný, Václav (UMCH-V) RID, ORCID
Jäger, Eliezer (UMCH-V) ORCID, RIDZdroj.dok. ACS Omega. - : American Chemical Society - ISSN 2470-1343
Roč. 7, č. 47 (2022), s. 42711-42722Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova polymerization-induced self-assembly ; block copolymers ; nano-objects Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP GJ20-15077Y GA ČR - Grantová agentura ČR GA21-01090S GA ČR - Grantová agentura ČR LM2018133 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000888029200001 EID SCOPUS 85142662607 DOI 10.1021/acsomega.2c04036 Anotace Herein, we present a versatile platform for the synthesis of pH-responsive poly([N-(2-hydroxypropyl)]methacrylamide)-b-poly[2-(diisopropylamino)ethyl methacrylate] diblock copolymer (PHPMA-b-PDPA) nanoparticles (NPs) obtained via microwave-assisted reversible addition–fragmentation chain transfer polymerization-induced self-assembly (MWI-PISA). The N-(2-hydroxypropyl) methacrylamide (HPMA) monomer was first polymerized to obtain a macrochain transfer agent with polymerization degrees (DPs) of 23 and 51. Subsequently, using mCTA and 2-(diisopropylamino)ethyl methacrylate (DPA) as monomers, we successfully conducted MWI-PISA emulsion polymerization in aqueous solution with a solid content of 10 wt %. The NPs were obtained with high monomer conversion and polymerization rates. The resulting diblock copolymer NPs were analyzed by dynamic light scattering (DLS) and cryogenic-transmission electron microscopy (cryo-TEM). cryo-TEM studies reveal the presence of only NPs with spherical morphology such as micelles and polymer vesicles known as polymersomes. Under the selected conditions, we were able to fine-tune the morphology from micelles to polymersomes, which may attract considerable attention in the drug-delivery field. The capability for drug encapsulation using the obtained in situ pH-responsive NPs, the polymersomes based on PHPMA23-b-PDPA100, and the micelles based on PHPMA51-b-PDPA100 was demonstrated using the hydrophobic agent and fluorescent dye as Nile red (NR). In addition, the NP disassembly in slightly acidic environments enables fast NR release. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2023 Elektronická adresa https://pubs.acs.org/doi/10.1021/acsomega.2c04036
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