Liquid crystalline lipid nanoparticles for combined delivery of curcumin, fish oil and BDNF: In vitro neuroprotective potential in a cellular model of tunicamycin-induced endoplasmic reticulum stress

0560559 - FZÚ 2023 RIV CN eng J - Článek v odborném periodiku
Rakotoarisoa, M. - Angelov, Borislav - Drechsler, M. - Nicolas, V. - Bizien, T. - Gorshkova, Yu. E. - Deng, Y. - Angelova, A.
Liquid crystalline lipid nanoparticles for combined delivery of curcumin, fish oil and BDNF: In vitro neuroprotective potential in a cellular model of tunicamycin-induced endoplasmic reticulum stress.
Smart Materials in Medicine. Roč. 3, Jan (2022), s. 274-288. E-ISSN 2590-1834
Grant CEP: GA MŠMT EF15_003/0000447; GA MŠMT EF16_019/0000789
Grant ostatní: OP VVV - ELIBIO(XE) CZ.02.1.01/0.0/0.0/15_003/0000447; OP VVV - ADONIS(XE) CZ.02.1.01/0.0/0.0/16_019/0000789
Institucionální podpora: RVO:68378271
Klíčová slova: lipid liquid crystalline nanoparticles * nanomedicine * cubosome * spongosome * curcumin * brain-derived neurotrophic factor * neuroprotection * endoplasmic reticulum stress
Obor OECD: Biophysics
Způsob publikování: Open access

We develop multidrug-loaded cubosome and spongosome lipid nanoparticles for targeting of endoplasmic reticulum stress as a potential emerging therapeutic strategy against neuronal degeneration. The multicompartment organization of the liquid crystalline nanoparticles (LCNPs), fabricated by self-assembly, was characterized by cryogenic transmission electron microscopy (cryo-TEM) and small-angle X-ray scattering (SAXS). Monoolein-based cubosome and spongosome LCNPs co-encapsulated the natural plant-derived antioxidant curcumin, fish oil rich in ω-3 polyunsaturated fatty acids (PUFA), and the neurotrophin brain-derived neurotrophic factor (BDNF), which is of vital need for neurogenesis. The neuroprotective properties of the nanoparticles were in vitro investigated in a cellular model of tunicamycin-induced endoplasmic reticulum (ER) stress using differentiated human neuroblastoma SH-SY5Y cells deprieved from serum.
Trvalý link: https://hdl.handle.net/11104/0333429