Počet záznamů: 1
Branched and linear fatty acid esters of hydroxy fatty acids (FAHFA) relevant to human health
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SYSNO ASEP 0556127 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Branched and linear fatty acid esters of hydroxy fatty acids (FAHFA) relevant to human health Tvůrce(i) Riečan, Martin (FGU-C) ORCID
Palůchová, Veronika (FGU-C) ORCID, RID
Lopes, Magno (FGU-C)
Brejchová, Kristýna (FGU-C) ORCID, RID, SAI
Kuda, Ondřej (FGU-C) RID, ORCID, SAICelkový počet autorů 5 Číslo článku 107972 Zdroj.dok. Pharmacology and Therapeutics. - : Elsevier - ISSN 0163-7258
Roč. 231, Mar (2022)Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova FAHFA ; OAHFA ; PAHSA ; meibum ; cytochrome P450 ; inhibitors Obor OECD Biochemistry and molecular biology CEP LTAUSA18104 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora FGU-C - RVO:67985823 UT WOS 000766822100015 EID SCOPUS 85114251796 DOI 10.1016/j.pharmthera.2021.107972 Anotace Fatty acid esters of hydroxy fatty acids (FAHFAs) represent a complex lipid class that contains both signaling mediators and structural components of lipid biofilms in humans. The majority of endogenous FAHFAs share a common chemical architecture, characterized by an estolide bond that links the hydroxy fatty acid (HFA) backbone and the fatty acid (FA). Two structurally and functionally distinct FAHFA superfamilies are recognized based on the position of the estolide bond: omega-FAHFAs and in-chain branched FAHFAs. The existing variety of possible HFAs and FAs combined with the position of the estolide bond generates a vast quantity of unique structures identified in FAHFA families. In this review, we discuss the anti-diabetic and anti-inflammatory effects of branched FAHFAs and the role of omega-FAHFA-derived lipids as surfactants in the tear film lipid layer and dry eye disease. To emphasize potential pharmacological targets, we recapitulate the biosynthesis of the HFA backbone within the superfamilies together with the degradation pathways and the FAHFA regioisomer distribution in human and mouse adipose tissue. We propose a theoretical involvement of cytochrome P450 enzymes in the generation and degradation of saturated HFA backbones and present an overview of small-molecule inhibitors used in FAHFA research. The FAHFA lipid class is huge and largely unexplored. Besides the unknown biological effects of individual FAHFAs, also the enigmatic enzymatic machinery behind their synthesis could provide new therapeutic approaches for inflammatory metabolic or eye diseases. Therefore, understanding the mechanisms of (FA)HFA synthesis at the molecular level should be the next step in FAHFA research. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2023 Elektronická adresa https://doi.org/10.1016/j.pharmthera.2021.107972
Počet záznamů: 1