Počet záznamů: 1
Cortical network organization reflects clinical response to subthalamic nucleus deep brain stimulation in Parkinson's disease
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SYSNO ASEP 0549312 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Cortical network organization reflects clinical response to subthalamic nucleus deep brain stimulation in Parkinson's disease Tvůrce(i) Bočková, M. (CZ)
Výtvarová, E. (CZ)
Lamoš, M. (CZ)
Klimeš, Petr (UPT-D) RID, ORCID, SAI
Jurák, Pavel (UPT-D) RID, ORCID, SAI
Halámek, Josef (UPT-D) RID, ORCID, SAI
Goldemundová, S. (CZ)
Baláž, M. (CZ)
Rektor, I. (CZ)Celkový počet autorů 9 Zdroj.dok. Human Brain Mapping. - : Wiley - ISSN 1065-9471
Roč. 42, č. 17 (2021), s. 5626-5635Poč.str. 10 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova deep brain stimulation ; high-density EEG ; network analysis ; subthalamic nucleus Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Obor OECD Clinical neurology CEP NU21-04-00445 GA MZd - Ministerstvo zdravotnictví GA21-25953S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora UPT-D - RVO:68081731 UT WOS 000689718000001 EID SCOPUS 85113563918 DOI 10.1002/hbm.25642 Anotace The degree of response to subthalamic nucleus deep brain stimulation (STN-DBS) is individual and hardly predictable. We hypothesized that DBS-related changes in cortical network organization are related to the clinical effect. Network analysis based on graph theory was used to evaluate the high-density electroencephalography (HDEEG) recorded during a visual three-stimuli paradigm in 32 Parkinson's disease (PD) patients treated by STN-DBS in stimulation off and on states. Preprocessed scalp data were reconstructed into the source space and correlated to the behavioral parameters. In the majority of patients (n = 26), STN-DBS did not lead to changes in global network organization in large-scale brain networks. In a subgroup of suboptimal responders (n = 6), identified according to reaction times (RT) and clinical parameters (lower Unified Parkinson's Disease Rating Scale [UPDRS] score improvement after DBS and worse performance in memory tests), decreased global connectivity in the 1-8 Hz frequency range and regional node strength in frontal areas were detected. The important role of the supplementary motor area for the optimal DBS response was demonstrated by the increased node strength and eigenvector centrality in good responders. This response was missing in the suboptimal responders. Cortical topologic architecture is modified by the response to STN-DBS leading to a dysfunction of the large-scale networks in suboptimal responders. Pracoviště Ústav přístrojové techniky Kontakt Martina Šillerová, sillerova@ISIBrno.Cz, Tel.: 541 514 178 Rok sběru 2022 Elektronická adresa https://onlinelibrary.wiley.com/doi/10.1002/hbm.25642
Počet záznamů: 1