Počet záznamů: 1
Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication
- 1.0545098 - ÚOCHB 2022 RIV CH eng J - Článek v odborném periodiku
Dejmek, Milan - Konkoľová, Eva - Eyer, Luděk - Straková, Petra - Svoboda, Pavel - Šála, Michal - Krejčová, Kateřina - Růžek, Daniel - Bouřa, Evžen - Nencka, Radim
Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication.
Viruses. Roč. 13, č. 8 (2021), č. článku 1585. E-ISSN 1999-4915
Grant CEP: GA MŠMT(CZ) EF16_019/0000729; GA MZd(CZ) NU20-05-00472; GA MŠMT(CZ) LTAUSA18016
Institucionální podpora: RVO:61388963 ; RVO:60077344
Klíčová slova: non-nucleotide inhibitor * RNA-dependent RNA polymerase * SAR-CoV-2 * COVID-19 * antiviral agents
Obor OECD: Microbiology; Microbiology (BC-A)
Impakt faktor: 5.818, rok: 2021
Způsob publikování: Open access
https://doi.org/10.3390/v13081585
SARS-CoV-2 has caused an extensive pandemic of COVID-19 all around the world. Key viral enzymes are suitable molecular targets for the development of new antivirals against SARS-CoV-2 which could represent potential treatments of the corresponding disease. With respect to its essential role in the replication of viral RNA, RNA-dependent RNA polymerase (RdRp) is one of the prime targets. HeE1-2Tyr and related derivatives were originally discovered as inhibitors of the RdRp of flaviviruses. Here, we present that these pyridobenzothiazole derivatives also significantly inhibit SARS-CoV-2 RdRp, as demonstrated using both polymerase- and cell-based antiviral assays.
Trvalý link: http://hdl.handle.net/11104/0321862
Počet záznamů: 1