Počet záznamů: 1
Sex Differences in Heart Disease
- 1.
SYSNO ASEP 0537912 Druh ASEP M - Kapitola v monografii Zařazení RIV C - Kapitola v knize Název Cardiac Mitochondria and Ischemia/Reperfusion Injury-Sex Differences Tvůrce(i) Drahota, Zdeněk (FGU-C) RID, ORCID
Hlaváčková, Markéta (FGU-C) RID, ORCID
Ošťádal, Bohuslav (FGU-C) RID, ORCIDZdroj.dok. Sex Differences in Heart Disease. - Cham : Springer International Publishing, 2020 / Dhalla Naranjan S. ; Ošťádal Bohuslav - ISBN 978-3-030-58676-8 Rozsah stran s. 257-265 Poč.str. 9 s. Poč.str.knihy 284 Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova sex ; heart ; mitochondria ; ischemia/reperfusion injury ; mitochondrial permeability transition pore Vědní obor RIV ED - Fyziologie Obor OECD Physiology (including cytology) CEP GJ19-04790Y GA ČR - Grantová agentura ČR Institucionální podpora FGU-C - RVO:67985823 DOI 10.1007/978-3-030-58677-5_15 Anotace It is now widely accepted that function of cardiac mitochondria is sex-dependent. Female mitochondria better utilize lipids and exhibit higher oxidative capacity in comparison with males. Our results have revealed that female cardiac mitochondria are more resistant to calcium-induced swelling as compared with the male myocardium, this suggests their better protection against mitochodrial permeability transition pore (PTP) opening.It seems to us that sex-dependent specificity of the PTP function is not the results of differences in its protein composition, since the male and female rat heart contains comparable amount of ATP synthase and its regulatory protein cyclophilinD (CypD). The higher hypoxic tolerance of the female cardiac mitochondria thus rather reflects sex differences in the regulation of PTP function, probably together with regulation of CypD by post-translational modifications. The precise knowledge of the composition of the PTP compex and regulation of pore opening are essential conditions for the development of new drugs targeting the function of PTP. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2021 Elektronická adresa https://doi.org/10.1007/978-3-030-58677-5_15
Počet záznamů: 1