Počet záznamů: 1
Interleaflet Coupling of Lipid Nanodomains – Insights From in vitro Systems
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SYSNO ASEP 0524199 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Interleaflet Coupling of Lipid Nanodomains – Insights From in vitro Systems Tvůrce(i) Sarmento, Maria Joäo (UFCH-W) ORCID, RID
Hof, Martin (UFCH-W) RID, ORCID
Šachl, Radek (UFCH-W) RID, ORCIDČíslo článku 284 Zdroj.dok. Frontiers in Cell and Developmental Biology. - : Frontiers Research Foundation - ISSN 2296-634X
Roč. 8, APR 2020 (2020)Poč.str. 16 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova domain registration ; interleaftet coupling ; membrane asymmetry Vědní obor RIV CF - Fyzikální chemie a teoretická chemie Obor OECD Physical chemistry CEP GX19-26854X GA ČR - Grantová agentura ČR GA18-04871S GA ČR - Grantová agentura ČR EF16_027/0008355 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UFCH-W - RVO:61388955 UT WOS 000533366400001 EID SCOPUS 85084520337 DOI 10.3389/fcell.2020.00284 Anotace The plasma membrane is a complex system, consisting of two layers of lipids and proteins compartmentalized into small structures called nanodomains. Despite the asymmetric composition of both leaflets, coupling between the layers is surprisingly strong. This can be evidenced, for example, by recent experimental studies performed on phospholipid giant unilamellar vesicles showing that nanodomains formed in the outer layer are perfectly registered with those in the inner leaflet. Similarly, microscopic phase separation in one leaflet can induce phase separation in the opposing leaflet that would otherwise be homogeneous. In this review, we summarize the current theoretical and experimental knowledge that led to the current view that domains are – irrespective of their size – commonly registered across the bilayer. Mechanisms inducing registration of nanodomains suggested by theory and calculations are discussed. Furthermore, domain coupling is evidenced by experimental studies based on the sparse number of methods that can resolve registered from independent nanodomains. Finally, implications that those findings using model membrane studies might have for cellular membranes are discussed. Pracoviště Ústav fyzikální chemie J.Heyrovského Kontakt Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Rok sběru 2021 Elektronická adresa http://hdl.handle.net/11104/0308581
Počet záznamů: 1