Advances in Disease Models

0523215 - ÚMG 2020 RIV CZ eng M - Část monografie knihy
Kozmik, Zbyněk
Eye organoids as a useful tool for studies of eye development and human ocular diseases.
Advances in Disease Models. Praha: OPTIO CZ, 2019 - (Bartůněk, P.), s. 49-56. ISBN 978-80-88011-06-4
Grant CEP: GA MŠMT LO1419
Institucionální podpora: RVO:68378050
Klíčová slova: eye organoids * eye development * human ocular diseases
Obor OECD: Cell biology

Organoid model represents a major technological breakthrough that has been developed to allow in vitro studies of tissues and organs. The organoids often possess cell type complexity, 3D organization and function that is remarkably similar to their in vivo counterparts. Eye organoids were successfully derived from pluripotent stem cells for the lens tissue, retina and retinal pigment epithelium. Combination of genetic, transcriptomic and proteomic approaches applied to eye organoids will undoubtedly reveal crucial aspects of development, homeostasis and disease of the human eye.
Trvalý link: http://hdl.handle.net/11104/0307592