Počet záznamů: 1
Diffusion Kurtosis Imaging Detects Microstructural Changes in a Methamphetamine-Induced Mouse Model of Parkinson's Disease
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SYSNO ASEP 0511376 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Diffusion Kurtosis Imaging Detects Microstructural Changes in a Methamphetamine-Induced Mouse Model of Parkinson's Disease Tvůrce(i) Arab, A. (CZ)
Rudá-Kučerová, J. (CZ)
Minsterová, A. (CZ)
Dražanová, Eva (UPT-D) RID, ORCID, SAI
Szabó, N. (CZ)
Starčuk jr., Zenon (UPT-D) RID, ORCID, SAI
Rektorová, I. (CZ)
Khairnar, A. (CZ)Celkový počet autorů 8 Zdroj.dok. Neurotoxicity Research. - : Springer - ISSN 1029-8428
Roč. 36, č. 4 (2019), s. 724-735Poč.str. 11 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova behaviour ; diffusion kurtosis imaging ; methamphetamine ; mice ; MRI ; Parkinson's disease ; tract-based spatial statistics Vědní obor RIV FS - Lékařská zařízení, přístroje a vybavení Obor OECD Neurosciences (including psychophysiology CEP EF16_013/0001775 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy LM2015062 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy ED0017/01/01 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora UPT-D - RVO:68081731 UT WOS 000494483100008 EID SCOPUS 85068093220 DOI 10.1007/s12640-019-00068-0 Anotace Methamphetamine (METH) abuse is known to increase the risk of Parkinson's disease (PD) due to its dopaminergic neurotoxicity. This is the rationale for the METH model of PD developed by toxic METH dosing (10 mg/kg four times every 2 h) which features robust neurodegeneration and typical motor impairment in mice. In this study, we used diffusion kurtosis imaging to reveal microstructural brain changes caused by METH-induced neurodegeneration. The METH-treated mice and saline-treated controls underwent diffusion kurtosis imaging scanning using the Bruker Avance 9.4 Tesla MRI system at two time-points: 5 days and 1 month to capture both early and late changes induced by METH. At 5 days, we found a decrease in kurtosis in substantia nigra, striatum and sensorimotor cortex, which is likely to indicate loss of DAergic neurons. At 1 month, we found an increase of kurtosis in striatum and sensorimotor cortex and hippocampus, which may reflect certain recovery processes. Furthermore, we performed tract-based spatial statistics analysis in the white matter and at 1 month, we observed increased kurtosis in ventral nucleus of the lateral lemniscus and some of the lateral thalamic nuclei. No changes were present at the early stage. This study confirms the ability of diffusion kurtosis imaging to detect microstructural pathological processes in both grey and white matter in the METH model of PD. The exact mechanisms underlying the kurtosis changes remain to be elucidated but kurtosis seems to be a valuable biomarker for tracking microstructural brain changes in PD and potentially other neurodegenerative disorders. Pracoviště Ústav přístrojové techniky Kontakt Martina Šillerová, sillerova@ISIBrno.Cz, Tel.: 541 514 178 Rok sběru 2020 Elektronická adresa https://link.springer.com/article/10.1007%2Fs12640-019-00068-0
Počet záznamů: 1