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Polymer brushes based on PLLA-b-PEO colloids for the preparation of protein resistant PLA surfaces
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SYSNO ASEP 0474915 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Polymer brushes based on PLLA-b-PEO colloids for the preparation of protein resistant PLA surfaces Tvůrce(i) Mázl Chánová, Eliška (UMCH-V) RID
Pop-Georgievski, Ognen (UMCH-V) RID, ORCID
Kumorek, Marta M. (UMCH-V) RID
Janoušková, Olga (UMCH-V) RID, SAI, ORCID
Machová, Luďka (UMCH-V) RID
Kubies, Dana (UMCH-V) RID, ORCID
Rypáček, František (UMCH-V) RIDZdroj.dok. Biomaterials Science . - : Royal Society of Chemistry - ISSN 2047-4830
Roč. 5, č. 6 (2017), s. 1130-1143Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova polymer brush ; poly(ethylene oxide) ; polylactide Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP GJ15-09368Y GA ČR - Grantová agentura ČR NV16-28254A GA MZd - Ministerstvo zdravotnictví LQ1604 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy ED1.1.00/02.0109 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000402376000007 EID SCOPUS 85021701852 DOI 10.1039/C7BM00009J Anotace In this study we investigate the formation of protein-resistant polymer surfaces, such as aliphatic polyesters, through the deposition of self-assemblies of amphiphilic poly(L-lactide)-b-poly(ethylene oxide), PLLA-b-PEO, copolymers as stable nanoparticles with a kinetically frozen PLLA core on model PLLA surfaces. The length of the PEO chains in the corona was tuned to achieve polymer brushes capable of preventing protein adsorption on PLA-based biomaterials. The spectroscopic ellipsometry, IR and XPS analysis, contact angle goniometry, and AFM proved that the PEO chains adopted a brush structure and were preferably exposed on the surface. The low-fouling properties of the physisorbed PLLA-b-PEO layers approached the ones of reactive grafting methods, as shown by surface plasmon resonance spectroscopy. The anti-fouling properties of the prepared PEO brushes provided sufficient interface to prevent cell adhesion as proved in vitro. Thus, the developed surface coating with PLLA-b-PEO colloids can provide an anti-fouling background for the creation of nanopatterned biofunctionalized surfaces in biomedical applications. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2018
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