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Macromolecular systems for vaccine delivery
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SYSNO ASEP 0463724 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Macromolecular systems for vaccine delivery Tvůrce(i) Mužíková, Gabriela (UMCH-V) RID
Laga, Richard (UMCH-V) RID, ORCIDZdroj.dok. Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 65, Suppl. 2 (2016), S203-S216Poč.str. 14 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova vaccine delivery ; cellular and humoral immunity ; polymer immunostimulants Vědní obor RIV EB - Genetika a molekulární biologie CEP LQ1604 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000386686800006 EID SCOPUS 84997269655 Anotace Vaccines have helped considerably in eliminating some lifethreatening infectious diseases in past two hundred years. Recently, human medicine has focused on vaccination against some of the world’s most common infectious diseases (AIDS, malaria, tuberculosis, etc.), and vaccination is also gaining popularity in the treatment of cancer or autoimmune diseases. The major limitation of current vaccines lies in their poor ability to generate a sufficient level of protective antibodies and T cell responses against diseases such as HIV, malaria, tuberculosis and cancers. Among the promising vaccination systems that could improve the potency of weakly immunogenic vaccines belong macromolecular carriers (water soluble polymers, polymer particels, micelles, gels etc.) conjugated with antigens and immunistumulatory molecules. The size, architecture, and the composition of the high molecular-weight carrier can significantly improve the vaccine efficiency. This review includes the most recently developed (bio)polymer-based vaccines reported in the literature. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2017 Elektronická adresa http://www.biomed.cas.cz/physiolres/pdf/65%20Suppl%202/65_S203.pdf
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