Počet záznamů: 1
Cell type-specific modulation of lipid mediator's formation in murine adipose tissue by omega-3 fatty acids
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SYSNO ASEP 0458422 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Cell type-specific modulation of lipid mediator's formation in murine adipose tissue by omega-3 fatty acids Tvůrce(i) Kuda, Ondřej (FGU-C) RID, ORCID, SAI
Rombaldová, Martina (FGU-C) RID, ORCID
Janovská, Petra (FGU-C) RID, ORCID
Flachs, Pavel (FGU-C) RID
Kopecký, Jan (FGU-C) RID, ORCIDZdroj.dok. Biochemical and Biophysical Research Communications. - : Elsevier - ISSN 0006-291X
Roč. 469, č. 3 (2016), s. 731-736Poč.str. 6 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova adipose tissue macrophages ; omega-3 PUFA ; protectin D1 ; lipid mediators ; lipidomics Vědní obor RIV EB - Genetika a molekulární biologie CEP GP13-04449P GA ČR - Grantová agentura ČR GA13-00871S GA ČR - Grantová agentura ČR LH14040 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Institucionální podpora FGU-C - RVO:67985823 UT WOS 000369352800062 EID SCOPUS 84953635674 DOI 10.1016/j.bbrc.2015.12.055 Anotace The fractionation and metabolipidomic analysis were used to identify cells producing lipid mediators in epididymal WAT of mice fed for 5 weeks obesogenic high-fat diet (lipid content 35% wt/wt), which was supplemented or not by omega-3 PUFA (4.3 mg eicosapentaenoic acid and 14.7 mg docosahexaenoic acid per g of diet). Our results demonstrate selective increase in levels of anti-inflammatory lipid mediators in WAT in response to omega-3, reflecting either their association with adipocytes (endocannabinoid-related N-docosahexaenoylethanolamine) or with stromal vascular cells (pro-resolving lipid mediator protectin D1). These results further document specific roles of various cell types in WAT in control of WAT inflammation and metabolism and they suggest that also other cells but ATMs are engaged in production of proresolving lipid mediators in response to omega-3 PUFA. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2017
Počet záznamů: 1