Excess  NF-kB induces  ectopic  odontogenesis  in embryonic  incisor  epithelium

Blackburn, J.; Kawasaki, K.; Porntaveetus, T.; Kawasaki, M.; Otsuka-Tanaka, Y.; Miake, Y.; Ota, M. S.; Watanabe, M.; Hishinuma, M.; Nomoto, T.; Oommen, S.; Ghafoor, S.; Harada, F.; Nozawa-Inoue, K.; Maeda, T.; Peterková, Renata; Lesot, H.; Inoue, J.; Akiyama, T.; Schmidt-Ulrich, R.; Liu, B.; Hu, Y.; Page, A.; Ramírez, Á.; Sharpe, P. T.; Ohazama, A.

doi:https://dx.doi.org/10.1177/0022034514556707

Počet záznamů: 1

Excess NF-kB induces ectopic odontogenesis in embryonic incisor epithelium

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SYSNO ASEP	0438519
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Excess NF-kB induces ectopic odontogenesis in embryonic incisor epithelium
Tvůrce(i)	Blackburn, J. (GB) Kawasaki, K. (GB) Porntaveetus, T. (GB) Kawasaki, M. (GB) Otsuka-Tanaka, Y. (GB) Miake, Y. (JP) Ota, M. S. (JP) Watanabe, M. (JP) Hishinuma, M. (JP) Nomoto, T. (JP) Oommen, S. (GB) Ghafoor, S. (GB) Harada, F. (GB) Nozawa-Inoue, K. (GB) Maeda, T. (JP) Peterková, Renata (UEM-P)_RID Lesot, H. (FR) Inoue, J. (JP) Akiyama, T. (JP) Schmidt-Ulrich, R. (DE) Liu, B. (US) Hu, Y. (US) Page, A. (ES) Ramírez, Á. (ES) Sharpe, P. T. (GB) Ohazama, A. (GB)
Zdroj.dok.	Journal of Dental Research. - : Sage - ISSN 0022-0345 Roč. 94, č. 1 (2015), s. 121-128
Poč.str.	8 s.
Jazyk dok.	eng - angličtina
Země vyd.	US - Spojené státy americké
Klíč. slova	incisor ; tooth development
Vědní obor RIV	EA - Morfologické obory a cytologie
CEP	GB14-37368G GA ČR - Grantová agentura ČR
Institucionální podpora	UEM-P - RVO:68378041
UT WOS	000346506200016
EID SCOPUS	84919464755
DOI	10.1177/0022034514556707
Anotace	Nuclear factor kappa B (NF-κB) signaling plays critical roles in many physiological and pathological processes, including regulating organogenesis. Down-regulation of NF-κB signaling during development results in hypohidrotic ectodermal dysplasia. The roles of NF-κB signaling in tooth development, however, are not fully understood. We examined mice overexpressing IKKβ, an essential component of the NF-κB pathway, under keratin 5 promoter (K5-Ikkβ). K5-Ikkβ mice showed supernumerary incisors whose formation was accompanied by up-regulation of canonical Wnt signaling. Apoptosis that is normally observed in wild-type incisor epithelium was reduced in K5-Ikkβ mice. The supernumerary incisors in K5-Ikkβ mice were found to phenocopy extra incisors in mice with mutations of Wnt inhibitor, Wise. Excess NF-κB activity thus induces an ectopic odontogenesis program that is usually suppressed under physiological conditions.
Pracoviště	Ústav experimentální medicíny
Kontakt	Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218
Rok sběru	2016

Počet záznamů: 1