Počet záznamů: 1
Bacteria and their Toxins Tamed for Immunotherapy
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SYSNO ASEP 0381770 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Bacteria and their Toxins Tamed for Immunotherapy Tvůrce(i) Adkins, Irena (MBU-M)
Holubová, Jana (MBU-M) RID, ORCID
Kosová, Martina (MBU-M)
Sadílková, Lenka (MBU-M)Zdroj.dok. Current Pharmaceutical Biotechnology - ISSN 1389-2010
Roč. 13, č. 8 (2012), s. 1446-1473Poč.str. 28 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Adjuvant ; antigen delivery ; antigen presentation Vědní obor RIV CE - Biochemie CEP GP310/09/P582 GA ČR - Grantová agentura ČR GA310/08/0447 GA ČR - Grantová agentura ČR Institucionální podpora MBU-M - RVO:61388971 UT WOS 000304596600009 Anotace Bacterial toxins share the ability to enter host cells to target various intracellular proteins and to modulate host immune responses. Over the last 20 years, toxins and their mutated variants, as well as live attenuated bacteria, have been exploited for vaccination and immunotherapy of various infectious, malignant and autoimmune diseases. The ability of Bordetella pertussis adenylate cyclase toxin to translocate its adenylate cyclase domain across the host cell membrane, as well as the pathways of intracellular trafficking of Bacillus anthracis lethal and edema toxins, Shigella dysenteriae shiga toxin or Escherichia coli shiga-like toxin, have been repeatedly exploited for the delivery of antigenic epitopes into host cells and for stimulation of antigen-specific T cell responses Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2013
Počet záznamů: 1