Počet záznamů: 1
GCPII Variants, Paralogs and Orthologs
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SYSNO ASEP 0377922 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název GCPII Variants, Paralogs and Orthologs Tvůrce(i) Hlouchová, Klára (UOCHB-X) ORCID
Navrátil, Václav (UOCHB-X) RID, ORCID
Tykvart, Jan (UOCHB-X) RID, ORCID
Šácha, Pavel (UOCHB-X) RID, ORCID
Konvalinka, Jan (UOCHB-X) RID, ORCIDCelkový počet autorů 5 Zdroj.dok. Current Medicinal Chemistry. - : Bentham Science Publishers - ISSN 0929-8673
Roč. 19, č. 9 (2012), s. 1316-1322Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova PSMA ; GCPIII ; NAALADase L ; splice variants ; homologs ; PSMAL Vědní obor RIV CE - Biochemie CEP GAP304/12/0847 GA ČR - Grantová agentura ČR CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000300641400009 DOI 10.2174/092986712799462676 Anotace Glutamate carboxypeptidase II (GCPII) and its splice variants, paralogs and human homologs represent a family of proteins with diverse tissue distribution, cellular localization and largely unknown function which have been explored only recently. While GCPII itself has been thoroughly studied from different perspectives, as clearly documented in this series of reviews, very little is known about other members of its family, even though they might be biologically relevant. Differential expression of individual GCPII splice variants is associated with tumor progression and prognosis of prostate cancer. The best studied GCPII homolog, GCPIII or NAALADase II, may be a valid pharmaceutical target for itself since it may compensate for a lack of normal GCPII enzymatic activity. Detailed molecular characterization of this family of proteins is thus very important not only with respect to the potential therapeutic use of GCPII inhibitors, but also for better understanding of the biological role of GCPII within as well as outside the nervous system. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2013
Počet záznamů: 1