0355817 - ÚMG 2011 RIV US eng J - Článek v odborném periodiku
Philimonenko, Anatoly - Janáček, Jiří - Snyers, L. - Almeder, M. - Berger, W. - Schmidt, W. - Schofer, C. - Hozák, Pavel
Chromosomal dynamics of cell cycle regulator gene p21 during transcriptional activation.
Journal of Structural Biology. Roč. 173, č. 2 (2011), s. 382-390. ISSN 1047-8477. E-ISSN 1095-8657
Grant CEP: GA MŠMT LC545; GA MŠMT(CZ) LC06063; GA MŠMT 2B06063
Výzkumný záměr: CEZ:AV0Z50520514; CEZ:AV0Z50110509
Klíčová slova: Chromosome territory * Gene expression * Confocal imaging
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 3.406, rok: 2011
DOI: https://doi.org/10.1016/j.jsb.2010.10.010

In this study we analyzed the position of the cell cycle regulator gene p21 within the CT of human chromosome 6 (HSA6) upon transcriptional activation. Whereas the majority of active p21 genes is located in the interior of the CT of HSA6, induction of p21 transcription correlates with increased variation of gene localization within the CT and with a higher percentage of p21 genes located at the periphery of the CT. Additionally it demonstrates once more that transcription can take place throughout CTs. Comparison of the p21 locus with two non-coding regions on HSA6 showed that both non-coding sequences are located more frequently in the interior of the CT than p21 genes although they are situated in chromosomal neighborhoods with widely differing gene density and regional transcriptional activity. Thus our data support models describing an influence of the transcriptional activity of a gene on the localization within its CT.

Trvalý link: http://hdl.handle.net/11104/0194498