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Ventral posterolateral and ventral posteromedial thalamocortical neurons have distinct physiological properties
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SYSNO ASEP 0581990 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Ventral posterolateral and ventral posteromedial thalamocortical neurons have distinct physiological properties Tvůrce(i) Studtmann, C. (US)
Ladislav, M. (US)
Safari, M. (US)
Khondaker, R. (US)
Chen, Y. (US)
Vaughan, G. A. (US)
Topolski, M. A. (US)
Tomović, E. (US)
Balík, Aleš (FGU-C) RID, ORCID
Swanger, S. A. (US)Zdroj.dok. Journal of Neurophysiology - ISSN 0022-3077
Roč. 130, č. 6 (2023), s. 1492-1507Poč.str. 16 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova somatosensory thalamus ; synaptic transmission ; thalamocortical neuron ; ventral posterolateral nucleus ; ventral posteromedial nucleus Obor OECD Neurosciences (including psychophysiology CEP LTAUSA19122 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora FGU-C - RVO:67985823 UT WOS 001127158500002 EID SCOPUS 85180011305 DOI 10.1152/jn.00525.2022 Anotace Somatosensory information is propagated from the periphery to the cerebral cortex by two parallel pathways through the ventral posterolateral (VPL) and ventral posteromedial (VPM) thalamus. VPL and VPM neurons receive somatosensory signals from the body and head, respectively. VPL and VPM neurons may also receive cell type-specific GABAergic input from the reticular nucleus of the thalamus. Although VPL and VPM neurons have distinct connectivity and physiological roles, differences in their functional properties remain unclear as they are often studied as one ventrobasal thalamus neuron population. Here, we directly compared synaptic and intrinsic properties of VPL and VPM neurons in C57Bl/6J mice of both sexes aged P25-P32. VPL neurons showed greater depolarization-induced spike firing and spike frequency adaptation than VPM neurons. VPL and VPM neurons fired similar numbers of spikes during hyperpolarization rebound bursts, but VPM neurons exhibited shorter burst latency compared with VPL neurons, which correlated with larger sag potential. VPM neurons had larger membrane capacitance and more complex dendritic arbors. Recordings of spontaneous and evoked synaptic transmission suggested that VPL neurons receive stronger excitatory synaptic input, whereas inhibitory synapse strength was stronger in VPM neurons. This work indicates that VPL and VPM thalamocortical neurons have distinct intrinsic and synaptic properties. The observed functional differences could have important implications for their specific physiological and pathophysiological roles within the somatosensory thalamocortical network. NEW & NOTEWORTHY This study revealed that somatosensory thalamocortical neurons in the VPL and VPM have substantial differences in excitatory synaptic input and intrinsic firing properties. The distinct properties suggest that VPL and VPM neurons could process somatosensory information differently and have selective vulnerability to disease. This work improves our understanding of nucleus-specific neuron function in the thalamus and demonstrates the critical importance of studying these parallel somatosensory pathways separately. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2024 Elektronická adresa https://doi.org./10.1152/jn.00525.2022
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