Počet záznamů: 1
Exceptionally fast temperature-responsive, mechanically strong and extensible monolithic non-porous hydrogels: poly(N-isopropylacrylamide) intercalated with hydroxypropyl methylcellulose
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SYSNO ASEP 0580772 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Exceptionally fast temperature-responsive, mechanically strong and extensible monolithic non-porous hydrogels: poly(N-isopropylacrylamide) intercalated with hydroxypropyl methylcellulose Tvůrce(i) Strachota, Beata (UMCH-V) RID
Strachota, Adam (UMCH-V) RID, ORCID
Vratović, Leana (UMCH-V)
Pavlova, Ewa (UMCH-V) RID
Šlouf, Miroslav (UMCH-V) RID, ORCID
Kamel, S. (EG)
Cimrová, Věra (UMCH-V) RID, ORCIDČíslo článku 926 Zdroj.dok. Gels. - : MDPI
Roč. 9, č. 12 (2023)Poč.str. 25 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova hydrogels ; drug release ; smart materials Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 001131988500001 EID SCOPUS 85180715788 DOI 10.3390/gels9120926 Anotace Exceptionally fast temperature-responsive, mechanically strong, tough and extensible monolithic non-porous hydrogels were synthesized. They are based on divinyl-crosslinked poly(N-isopropyl-acrylamide) (PNIPAm) intercalated by hydroxypropyl methylcellulose (HPMC). HPMC was largely extracted after polymerization, thus yielding a ‘template-modified’ PNIPAm network intercalated with a modest residue of HPMC. High contents of divinyl crosslinker and of HPMC caused a varying degree of micro-phase-separation in some products, but without detriment to mechanical or tensile properties. After extraction of non-fixed HPMC, the micro-phase-separated products combine superior mechanical properties with ultra-fast T-response (in 30 s). Their PNIPAm network was highly regular and extensible (intercalation effect), toughened by hydrogen bonds to HPMC, and interpenetrated by a network of nano-channels (left behind by extracted HPMC), which ensured the water transport rates needed for ultra-fast deswelling. Moreover, the T-response rate could be widely tuned by the degree of heterogeneity during synthesis. The fastest-responsive among our hydrogels could be of practical interest as soft actuators with very good mechanical properties (soft robotics), while the slower ones offer applications in drug delivery systems (as tested on the example of Theophylline), or in related biomedical engineering applications. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2024 Elektronická adresa https://www.mdpi.com/2310-2861/9/12/926
Počet záznamů: 1