Počet záznamů: 1
Pathogenicity and virulence of Borrelia burgdorferi
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SYSNO ASEP 0577349 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Pathogenicity and virulence of Borrelia burgdorferi Tvůrce(i) Strnad, Martin (BC-A) ORCID
Rudenko, Natalia (BC-A) RID, ORCID
Rego, Ryan O. M. (BC-A) RID, ORCIDCelkový počet autorů 3 Číslo článku 2265015 Zdroj.dok. Virulence. - : Taylor & Francis - ISSN 2150-5594
Roč. 14, č. 1 (2023)Poč.str. 31 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Borrelia burgdorferi ; Lyme disease ; virulence determinants ; pathogenicity ; clinical manifestations ; tick-borne disease Vědní obor RIV CE - Biochemie Obor OECD Biochemistry and molecular biology CEP GF22-18647K GA ČR - Grantová agentura ČR GC23-06525J GA ČR - Grantová agentura ČR NV19-05-00191 GA MZd - Ministerstvo zdravotnictví Způsob publikování Open access Institucionální podpora BC-A - RVO:60077344 UT WOS 001081459900001 EID SCOPUS 85173647428 DOI 10.1080/21505594.2023.2265015 Anotace Infection with Borrelia burgdorferi often triggers pathophysiologic perturbations that are further augmented by the inflammatory responses of the host, resulting in the severe clinical conditions of Lyme disease. While our apprehension of the spatial and temporal integration of the virulence determinants during the enzootic cycle of B. burgdorferi is constantly being improved, there is still much to be discovered. Many of the novel virulence strategies discussed in this review are undetermined. Lyme disease spirochaetes must surmount numerous molecular and mechanical obstacles in order to establish a disseminated infection in a vertebrate host. These barriers include borrelial relocation from the midgut of the feeding tick to its body cavity and further to the salivary glands, deposition to the skin, haematogenous dissemination, extravasation from blood circulation system, evasion of the host immune responses, localization to protective niches, and establishment of local as well as distal infection in multiple tissues and organs. Here, the various well-defined but also possible novel strategies and virulence mechanisms used by B. burgdorferi to evade obstacles laid out by the tick vector and usually the mammalian host during colonization and infection are reviewed. Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2024 Elektronická adresa https://www.tandfonline.com/doi/full/10.1080/21505594.2023.2265015
Počet záznamů: 1