Počet záznamů: 1
Extracellular vesicles secreted by Echinococcus multilocularis: important players in angiogenesis promotion
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SYSNO ASEP 0576966 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Extracellular vesicles secreted by Echinococcus multilocularis: important players in angiogenesis promotion Tvůrce(i) Liu, C. (CN)
Cao, J. (CN)
Zhang, H. (CN)
Field, Mark Christian (BC-A) ORCID
Yin, J. (SA)Celkový počet autorů 5 Číslo článku 105147 Zdroj.dok. Microbes and Infection. - : Elsevier - ISSN 1286-4579
Roč. 25, č. 7 (2023)Poč.str. 11 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova Echinococcus multilocularis ; Protoscoleces ; Extracellular vesicle ; Exosome ; Proteomics ; Angiogenesis Vědní obor RIV EC - Imunologie Obor OECD Immunology Způsob publikování Open access Institucionální podpora BC-A - RVO:60077344 UT WOS 001079101800001 EID SCOPUS 85167365968 DOI 10.1016/j.micinf.2023.105147 Anotace The involvement of Echinococcus multilocularis, and other parasitic helminths, in regulating host physi-ology is well recognized, but molecular mechanisms remain unclear. Extracellular vesicles (EVs) released by helminths play important roles in regulating parasite-host interactions by transferring materials to the host. Analysis of protein cargo of EVs from E. multilocularis protoscoleces in the present study revealed a unique composition exclusively associated with vesicle biogenesis. Common proteins in various Echinococcus species were identified, including the classical EVs markers tetraspanins, TSG101 and Alix. Further, unique tegumental antigens were identified which could be exploited as Echinococcus EV markers. Parasite-and host-derived proteins within these EVs are predicted to support important roles in parasite-parasite and parasite-host communication. In addition, the enriched host-derived protein payloads identified in parasite EVs in the present study suggested that they can be involved in focal adhesion and potentially promote angiogenesis. Further, increased angiogenesis was observed in livers of mice infected with E. multilocularis and the expression of several angiogenesis-regulated mol-ecules, including VEGF, MMP9, MCP-1, SDF-1 and serpin E1 were increased. Significantly, EVs released by the E. multilocularis protoscolex promoted proliferation and tube formation by human umbilical vein endothelial cells (HUVECs) in vitro. Taken together, we present the first evidence that tapeworm-secreted EVs may promote angiogenesis in Echinococcus-infections, identifying central mechanisms of Echino-coccus-host interactions.(c) 2023 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Pracoviště Biologické centrum (od r. 2006) Kontakt Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Rok sběru 2024 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S1286457923000503?via%3Dihub
Počet záznamů: 1