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Small secreted proteins and exocytosis regulators: do they go along?

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    0571048 - ÚEB 2024 RIV GB eng J - Článek v odborném periodiku
    Pečenková, Tamara - Potocký, Martin
    Small secreted proteins and exocytosis regulators: do they go along?
    Plant Signaling & Behavior. Roč. 18, č. 1 (2023), č. článku 2163340. ISSN 1559-2316. E-ISSN 1559-2324
    Grant CEP: GA MŠMT(CZ) EF16_019/0000738
    Institucionální podpora: RVO:61389030
    Klíčová slova: cle * co-expression * exocyst * pr1 * secretion * snare
    Obor OECD: Biochemistry and molecular biology
    Impakt faktor: 2.9, rok: 2022
    Způsob publikování: Open access
    https://doi.org/10.1080/15592324.2022.2163340

    Small secreted proteins play an important role in plant development, as well as in reactions to changes in the environment. In Arabidopsis thaliana, they are predominantly members of highly expanded families, such as the pathogenesis-related (PR) 1-like protein family, whose most studied member PR1 is involved in plant defense responses by a so far unknown mechanism, or Clavata3/Endosperm Surrounding Region (CLE) protein family, whose members’ functions in the development are well described. Our survey of the existing literature for the two families showed a lack of details on their localization, trafficking, and exocytosis. Therefore, in order to uncover the modes of their secretion, we tested the hypothesis that a direct link between the secreted cargoes and the secretion regulators such as Rab GTPases, SNAREs, and exocyst subunits could be established using in silico co-expression and clustering approaches. We employed several independent techniques to uncover that only weak co-expression links could be found for limited numbers of secreted cargoes and regulators. We propose that there might be particular spatio-temporal requirements for PR1 and CLE proteins to be synthesized and secreted, and efforts to experimentally cover these discrepancies should be invested along with functional studies.
    Trvalý link: https://hdl.handle.net/11104/0342358

     
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