Počet záznamů: 1
Pharmacokinetics of intramuscularly administered thermoresponsive polymers
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SYSNO ASEP 0564350 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Pharmacokinetics of intramuscularly administered thermoresponsive polymers Tvůrce(i) Groborz, Ondřej (UMCH-V) ORCID, RID
Kolouchová, Kristýna (UMCH-V) ORCID, RID
Pankrác, J. (CZ)
Keša, P. (CZ)
Kadlec, J. (IL)
Krunclová, Tereza (UMCH-V) ORCID
Pierzynová, A. (CZ)
Šrámek, J. (CZ)
Hovořáková, M. (CZ)
Dalecká, L. (CZ)
Pavlíková, Z. (CZ)
Matouš, P. (CZ)
Páral, P. (CZ)
Loukotová, L. (CZ)
Švec, P. (CZ)
Beneš, Hynek (UMCH-V) RID, ORCID
Štěpánek, L. (CZ)
Dunlop, D. (CZ)
Melo, C. V. (CZ)
Šefc, L. (CZ)
Slanina, T. (CZ)
Beneš, J. (CZ)
van Vlierberghe, S. (BE)
Hoogenboom, R. (BE)
Hrubý, Martin (UMCH-V) RID, ORCIDČíslo článku 2201344 Zdroj.dok. Advanced Healthcare Materials. - : Wiley - ISSN 2192-2640
Roč. 11, č. 22 (2022)Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova biodistribution ; LCST ; poly(2,2-difluoroethyl)acrylamide Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP TO01000074 GA TA ČR - Technologická agentura ČR LTC19032 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA21-04166S GA ČR - Grantová agentura ČR Výzkumná infrastruktura Czech-BioImaging II - 90129 - Ústav molekulární genetiky AV ČR, v. v. i. Způsob publikování Open access Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000879463300001 EID SCOPUS 85141470993 DOI 10.1002/adhm.202201344 Anotace Aqueous solutions of some polymers exhibit a lower critical solution temperature (LCST), that is, they form phase-separated aggregates when heated above a threshold temperature. Such polymers found many promising (bio)medical applications, including in situ thermogelling with controlled drug release, polymer-supported radiotherapy (brachytherapy), immunotherapy, and wound dressing, among others. Yet, despite the extensive research on medicinal applications of thermoresponsive polymers, their biodistribution and fate after administration remained unknown. Thus, herein, they studied the pharmacokinetics of four different thermoresponsive polyacrylamides after intramuscular administration in mice. In vivo, these thermoresponsive polymers formed depots that subsequently dissolved with a two-phase kinetics (depot maturation, slow redissolution) with half-lives 2 weeks to 5 months, as depot vitrification prolonged their half-lives. Additionally, the decrease of TCP of a polymer solution increased the density of the intramuscular depot. Moreover, they detected secondary polymer depots in the kidneys and liver, these secondary depots also followed two-phase kinetics (depot maturation and slow dissolution), with half-lives 8 to 38 days (kidneys) and 15 to 22 days (liver). Overall, these findings may be used to tailor the properties of thermoresponsive polymers to meet the demands of their medicinal applications. Their methods may become a benchmark for future studies of polymer biodistribution.
Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2023 Elektronická adresa https://onlinelibrary.wiley.com/doi/10.1002/adhm.202201344
Počet záznamů: 1