Počet záznamů: 1
Anxiety in Duckweed–Metabolism and Effect of Diazepam on Lemna minor
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SYSNO ASEP 0563405 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Anxiety in Duckweed–Metabolism and Effect of Diazepam on Lemna minor Tvůrce(i) Lamaczová, Adéla (BU-J)
Malina, Tomáš (BU-J)
Maršálková, Eliška (BU-J) ORCID, SAI
Odehnalová, Klára (BU-J) ORCID, RID
Opatřilová, R. (CZ)
Přibilová, Petra (BU-J) ORCID
Zezulka, Štěpán (BU-J) ORCID
Maršálek, Blahoslav (BU-J) ORCID, SAIČíslo článku 1484 Zdroj.dok. Water. - : MDPI
Roč. 14, č. 9 (2022)Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova Lemna minor ; benzodiazepines ; diazepam, oxazepam, temazepam, nordazepam ; ecotoxicology ; surface water ; aquatic plants ; phytoremediation Vědní obor RIV EH - Ekologie - společenstva Obor OECD Ecology CEP SS01020006 GA TA ČR - Technologická agentura ČR Způsob publikování Open access Institucionální podpora BU-J - RVO:67985939 UT WOS 000796106900001 EID SCOPUS 85130189332 DOI 10.3390/w14091484 Anotace The fate of pharmaceuticals in the human body, from their absorption to excretion is well studied. However, medication often leaves the patient's body in an unchanged or metabolised, yet still active, form. Diazepam and its metabolites, ranging up to 100 mu g/L, have been detected in surface waters worldwide, therefore, the question of its influence on model aquatic plants, such as duckweed (Lemna minor), needs to be addressed. Lemna was cultivated in a Steinberg medium containing diazepam in three concentrations-0.2, 20, and 2000 mu g/L. The activity of superoxide dismutase (SOD) and catalase (CAT), leaf count, mass, and the fluorescence quantum yield of photosynthesis were assessed. The medium was also analysed by LC-MS/MS to determine the concentration of diazepam metabolites. Our results show no negative impact of diazepam on Lemna minor, even in concentrations significantly higher than those that are ecotoxicologically relevant. On the contrary, the influence of diazepam on Lemna suggests growth stimulation and a similarity to the effect diazepam has on the human body. The comparison to the human body may be accurate because gamma-Aminobutyric acid-like (GABA-like) receptors responsible for the effect in humans have also been recently described in plants. Therefore, our results can open an interesting scientific area, indicating that GABA receptors and interference with benzodiazepines are evolutionarily much older than previously anticipated. This could help to answer more questions related to the reaction of aquatic organisms to micropollutants such as psychopharmaceuticals. Pracoviště Botanický ústav Kontakt Martina Bartošová, martina.bartosova@ibot.cas.cz, ibot@ibot.cas.cz, Tel.: 271 015 242 ; Marie Jakšová, marie.jaksova@ibot.cas.cz, Tel.: 384 721 156-8 Rok sběru 2023 Elektronická adresa https://doi.org/10.3390/w14091484
Počet záznamů: 1