Počet záznamů: 1
Rose Bengal-modified upconverting nanoparticles: synthesis, characterization, and biological evaluation
- 1.0560844 - ÚMCH 2023 RIV CH eng J - Článek v odborném periodiku
Nahorniak, Mykhailo - Pop-Georgievski, Ognen - Velychkivska, Nadiia - Filipová, Marcela - Rydvalová, Eliška - Gunár, Kristýna - Matouš, P. - Kostiv, Uliana - Horák, Daniel
Rose Bengal-modified upconverting nanoparticles: synthesis, characterization, and biological evaluation.
Life. Roč. 12, č. 9 (2022), č. článku 1383. E-ISSN 2075-1729
Grant CEP: GA ČR(CZ) GA21-04420S; GA ČR(CZ) GA20-07313S
Institucionální podpora: RVO:61389013
Klíčová slova: upconverting * nanoparticles * Rose Bengal
Obor OECD: Polymer science
Impakt faktor: 3.2, rok: 2022
Způsob publikování: Open access
https://www.mdpi.com/2075-1729/12/9/1383
High-quality upconverting NaYF4:Yb3+,Er3+ nanoparticles (UCNPs, 26 nm in diameter) based on lanthanides were synthesized by a high-temperature coprecipitation method. The particles were modified by bisphosphonate-terminated poly(ethylene glycol) (PEG) and Rose Bengal (RB) photosensitizer. The particles were thoroughly characterized using transmission electron microscopy, dynamic light scattering, thermogravimetric analysis, FTIR, and X-ray photoelectron and upconversion luminescence spectroscopy in terms of morphology, hydrodynamic size, composition, and energy transfer to the photosensitizer. Moreover, the singlet oxygen generation from RB-containing UCNPs was investigated using 9,10-diphenylanthracene probe under 980 nm excitation. The cytotoxicity of UCNPs before and after conjugation with RB was evaluated on highly sensitive rat mesenchymal stem cells (rMSCs) and significant differences were found. Correspondingly, consi-derable variations in viability were revealed between the irradiated and non-irradiated rat glioma cell line (C6) exposed to RB-conjugated UCNPs. While the viability of rMSCs was not affected by the presence of UCNPs themselves, the cancer C6 cells were killed after the irradiation at 980 nm due to the reactive oxygen species (ROS) production, thus suggesting the potential of RB-conjugated PEG-modified UCNPs for applications in photodynamic therapy of cancer.
Trvalý link: https://hdl.handle.net/11104/0334452
Počet záznamů: 1