Počet záznamů: 1
Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers
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SYSNO ASEP 0558373 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Coupling BODIPY with nitrogen-doped graphene quantum dots to address the water solubility of photosensitizers Tvůrce(i) Jennifer Gomez, I. (CZ)
Russo, M. (CZ)
Arcidiacono, Orazio Angelo (BFU-R) ORCID
Sanchez-Carnerero, E.M. (CZ)
Klán, P. (CZ)
Zajíčková, L. (CZ)Celkový počet autorů 6 Zdroj.dok. Materials Chemistry Frontiers. - : Royal Society of Chemistry
Roč. 6, č. 12 (2022), s. 1719-1726Poč.str. 8 s. Forma vydání Tištěná - P Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova singlet oxygen generation ; photodynamic therapy ; carbon dots ; nanoparticles ; derivatives ; mechanisms ; molecules Vědní obor RIV CE - Biochemie Obor OECD 1.7 Other natural sciences Způsob publikování Omezený přístup Institucionální podpora BFU-R - RVO:68081707 UT WOS 000802645400001 EID SCOPUS 85131816322 DOI 10.1039/d2qm00200k Anotace The potential of photodynamic therapy (PDT) applications is based primarily on the selection of suitable photosensitizers (PSs). However, highly efficient PSs producing singlet oxygen and other reactive oxygen species (ROS) often have poor water solubility and tend to aggregate in biological media. The most common alternative strategy to address the solubility of PSs is based on difficult-to-control encapsulation or conjugation to liposomes, micelles, or other nanoparticles via surface non-covalent interactions. Covalent functionalization remains relatively unexplored for common PSs. Here, we report a strategy to use highly efficient but poorly water-soluble BODIPY PSs connected to the surface of nitrogen-doped graphene quantum dots (NGQDs) through controlled covalent functionalization. These NGQD-BODIPY PSs do not aggregate in aqueous solutions and generate ROS upon irradiation with visible light, with singlet-oxygen production quantum yields up to 83%. In vitro fluorescence bioimaging was used to confirm that the PSs reside mostly in the cytoplasmic region of human cervical cancer cells (HeLa), and the system reduced the cell viability by similar to 85% upon irradiation. Pracoviště Biofyzikální ústav Kontakt Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Rok sběru 2023 Elektronická adresa https://pubs.rsc.org/en/content/articlelanding/2022/QM/D2QM00200K
Počet záznamů: 1