Počet záznamů: 1
Immunoengineering strategies to enhance vascularization and tissue regeneration
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SYSNO ASEP 0557599 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Immunoengineering strategies to enhance vascularization and tissue regeneration Tvůrce(i) Zárubová, Jana (FGU-C) RID, ORCID
Hasani-Sadrabadi, M. M. (US)
Ardehali, R. (US)
Li, S. (US)Číslo článku 114233 Zdroj.dok. Advanced Drug Delivery Reviews. - : ELSEVIER SCIENCE BV - ISSN 0169-409X
Roč. 184, May (2022)Poč.str. 23 s. Jazyk dok. eng - angličtina Země vyd. NL - Nizozemsko Klíč. slova neutrophils ; macrophages ; T cells ; immunomodulation ; cell delivery ; extracellular vesicles ; biomaterial ; immune cell metabolism ; stiffness ; patterning Obor OECD Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction) Způsob publikování Omezený přístup Institucionální podpora FGU-C - RVO:67985823 UT WOS 000793595700004 EID SCOPUS 85126693038 DOI 10.1016/j.addr.2022.114233 Anotace Immune cells have emerged as powerful regulators of regenerative as well as pathological processes. The vast majority of regenerative immunoengineering efforts have focused on macrophages, however, growing evidence suggests that other cells of both the innate and adaptive immune system are as important for successful revascularization and tissue repair. Moreover, spatiotemporal regulation of immune cells and their signaling have a significant impact on the regeneration speed and the extent of functional recovery. In this review, we summarize the contribution of different types of immune cells to the healing process and discuss ways to manipulate and control immune cells in favor of vascularization and tissue regeneration. In addition to cell delivery and cell-free therapies using extracellular vesicles, we discuss in situ strategies and engineering approaches to attract specific types of immune cells and modulate their phenotypes. This field is making advances to uncover the extraordinary potential of immune cells and their secretome in the regulation of vascularization and tissue remodeling. Understanding the principles of immunoregulation will help us design advanced immunoengineering platforms to harness their power for tissue regeneration. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2023 Elektronická adresa https://doi.org/10.1016/j.addr.2022.114233
Počet záznamů: 1