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Stability and ultraviolet A photostability of silymarin polyphenols and its consequences for practical use in dermatology
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SYSNO ASEP 0557085 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Stability and ultraviolet A photostability of silymarin polyphenols and its consequences for practical use in dermatology Tvůrce(i) Kosina, P. (CZ)
Ryšavá, A. (CZ)
Vostálová, J. (CZ)
Papoušková, B. (CZ)
Biedermann, David (MBU-M) RID, ORCID
Ulrichová, J. (CZ)
Svobodová, A. (CZ)Číslo článku 113897 Zdroj.dok. Journal of Photochemistry and Photobiology A-Chemistry. - : Elsevier - ISSN 1010-6030
Roč. 429, 1 August (2022)Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova milk thistle ; quercetin ; oxidation ; flavonoids ; mechanisms ; silybin ; Silybum marianum ; Flavonolignan ; Flavonoid ; Stability ; Photostability ; Photodecomposition products Vědní obor RIV FO - Dermatovenerologie Obor OECD Dermatology and venereal diseases Způsob publikování Omezený přístup Institucionální podpora MBU-M - RVO:61388971 UT WOS 000782111200002 EID SCOPUS 85126626586 DOI 10.1016/j.jphotochem.2022.113897 Anotace Silymarin (SM), a complex mixture of polyphenols, flavonolignans and flavonoids, isolated from milk thistle seeds (Silybum marianum L. Gaertn., Asteraceae), is widely accepted as a phytomedicine for the treatment of numerous diseases of various etiology. Thanks to its manifold biological properties, i.e. anti-oxidant, anti-inflammatory, immunomodulatory, and regenerative attributes, SM is of interest for dermatological applications. The stability of SM components for dermal use in aqueous environments of varying pH, as well as their photostability after UVA irradiation, were studied here using UV/VIS spectroscopy and HPLC-MS. Isosilybin, silychristin and silydianin were found to be stable and UVA photostable. Silybin and mainly taxifolin were unstable in aqueous solutions but both were UVA photostable. Quercetin and 2,3-dehydrosilybin were unstable and dose dependent UVA-induced degradation was also found. The main UVA-induced degradation product of 2,3-dehydrosilybin (C24H19O10, m/z 467.0978) in aqueous solutions was detected by UHPLC-HRMS analysis and MSE spectra. The main UVA photodegradation product of 2,3-dehydrosilybin has a similar structural motif to the minor quercetin photoproduct (C14H9O7, m/z 289.0348), newly identified in this study. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2023 Elektronická adresa https://www.sciencedirect.com/science/article/pii/S1010603022001265?via%3Dihub
Počet záznamů: 1