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HLHS: Power of the Chick Model
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SYSNO ASEP 0557062 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název HLHS: Power of the Chick Model Tvůrce(i) Sedmera, David (FGU-C) RID, ORCID, SAI Celkový počet autorů 1 Číslo článku 113 Zdroj.dok. Journal of cardiovascular development and disease. - : MDPI
Roč. 9, č. 4 (2022)Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova left atrial ligation ; left ventricular hypoplasia ; hemodynamic alteration ; myocyte proliferation ; embryonic myocardium Obor OECD Cardiac and Cardiovascular systems CEP NU21-02-00402 GA MZd - Ministerstvo zdravotnictví Způsob publikování Open access Institucionální podpora FGU-C - RVO:67985823 UT WOS 000786862100001 EID SCOPUS 85129078979 DOI 10.3390/jcdd9040113 Anotace Background: Hypoplastic left heart syndrome (HLHS) is a rare but deadly form of human congenital heart disease, most likely of diverse etiologies. Hemodynamic alterations such as those resulting from premature foramen ovale closure or aortic stenosis are among the possible pathways. Methods: The information gained from studies performed in the chick model of HLHS is reviewed. Altered hemodynamics leads to a decrease in myocyte proliferation causing hypoplasia of the left heart structures and their functional changes. Conclusions: Although the chick phenocopy of HLHS caused by left atrial ligation is certainly not representative of all the possible etiologies, it provides many useful hints regarding the plasticity of the genetically normal developing myocardium under altered hemodynamic loading leading to the HLHS phenotype, and even suggestions on some potential strategies for prenatal repair. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2023 Elektronická adresa https://www.mdpi.com/2308-3425/9/4/113
Počet záznamů: 1