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Flavonolignans from silymarin do not intercalate into DNA: Rebuttal of data published in the paper J. Mol. Recognit. e2812 (2019)
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SYSNO ASEP 0543851 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Flavonolignans from silymarin do not intercalate into DNA: Rebuttal of data published in the paper J. Mol. Recognit. e2812 (2019) Tvůrce(i) Biedermann, David (MBU-M) RID, ORCID
Hurtová, Martina (MBU-M) ORCID
Biedermannová, Lada (BTO-N) RID, ORCID
Valentová, Kateřina (MBU-M) RID, ORCID
Křen, Vladimír (MBU-M) RID, ORCIDCelkový počet autorů 5 Číslo článku 2888 Zdroj.dok. Journal of Molecular Recognition. - : Wiley - ISSN 0952-3499
Roč. 34, č. 7 (2021)Poč.str. 3 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova Flavonolignans ; silymarin Vědní obor RIV CE - Biochemie Obor OECD Medicinal chemistry Vědní obor RIV – spolupráce Biotechnologický ústav - Biochemie CEP LTC18071 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Omezený přístup Institucionální podpora MBU-M - RVO:61388971 ; BTO-N - RVO:86652036 UT WOS 000621076600001 EID SCOPUS 85101342151 DOI 10.1002/jmr.2888 Anotace In this letter, we present our concerns about the publication Pawar SK, Jaldappagari S. Intercalation of a flavonoid, silibinin into DNA base pairs: Experimental and theoretical approach. J. Mol. Recog. 2019, e2812. Doi: 10.1002/jmr.2812, which deals with the interaction of the natural product silybin with DNA. In our opinion, the conclusions presented by Pawar et al. are not supported by the data and here we are detailing our concerns. The paper in question1 deals with the interaction of an important and widely used nutraceutical compound silybin (sometimes also called silibinin) with DNA, and the topic is investigated using both experimental and in silico approaches. We found several serious errors in this paper, which we analyze hereunder. The conclusions disprove the data from various clinical trials showing safe use of silymarin even at high doses of several grams/day administered for weeks.2 Specifically, the data seem to directly contradict a previous work,3 which— using the same or very similar methods—has not found any interaction between silybin and DNA. The misleading conclusions of this paper1 — if valid—would have serious safety, legal, and economic consequences due to widespread production, marketing, and use of silybin as nutraceutical and drug components. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2022 Elektronická adresa https://onlinelibrary.wiley.com/doi/abs/10.1002/jmr.2888
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