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Tissue-specific protective properties of lithium: comparison of rat kidney, erythrocytes and brain
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SYSNO ASEP 0542670 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Tissue-specific protective properties of lithium: comparison of rat kidney, erythrocytes and brain Tvůrce(i) Roubalová, Lenka (FGU-C) RID, ORCID, SAI
Vošahlíková, Miroslava (FGU-C) RID, ORCID, SAI
Slaninová, Jiřina (FGU-C)
Kaufman, Jonáš (FGU-C)
Alda, M. (CZ)
Svoboda, Petr (FGU-C) RID, ORCIDZdroj.dok. Naunyn-Schmiedeberg's Archives of Pharmacology. - : Springer - ISSN 0028-1298
Roč. 394, č. 5 (2021), s. 955-965Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova lithium ; rat tissues ; sleep deprivation ; Na+/K+-ATPase ; malondialdehyde Vědní obor RIV ED - Fyziologie Obor OECD Physiology (including cytology) CEP GA17-07070S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora FGU-C - RVO:67985823 UT WOS 000605531100002 EID SCOPUS 85099065211 DOI 10.1007/s00210-020-02036-4 Anotace Lithium (Li) represents a first choice mood stabilizer for bipolar disorder (BD). Despite extensive clinical use, questions regarding its mechanism of action and pathological mechanism of renal function impairment by Li remain open. The present study aimed to improve our knowledge in this area paying special attention to the relationship between the length of Li action, lipid peroxidation (LP), and Na+/K+-ATPase properties. The effects of therapeutic Li doses, administered daily to male Wistar rats for 1 (acute), 7 (short term) and 28 days (chronic), were studied. For this purpose, Na+/K+-ATPase activity measurements, [3H]ouabain binding and immunoblot analysis of alpha-Na+/K+-ATPase were performed. Li-induced LP was evaluated by determining the malondialdehyde concentration by HPLC. Sleep deprivation (SD) was used as an experimental approach to model the manic phase of BD. Results obtained from the kidney were compared to those obtained from erythrocytes and different brain regions in the same tested animals. Whereas treatment with therapeutic Li concentration did not bring any LP damage nor significant changes of Na+/K+-ATPase expression and [3H]ouabain binding in the kidney, it conferred strong protection against this type of damage in the forebrain cortex. Importantly, the observed changes in erythrocytes indicated changes in forebrain cortices. Thus, different resistance to SD-induced changes of LP and Na+/K+-ATPase was detected in the kidney, erythrocytes and the brain of Li-treated rats. Our study revealed the tissue-specific protective properties of Li against LP and Na+/K+-ATPase regulation. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2022 Elektronická adresa https://doi.org/10.1007/s00210-020-02036-4
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