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Emerging Roles of Exosomes in Huntington's Disease
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SYSNO ASEP 0542475 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Emerging Roles of Exosomes in Huntington's Disease Tvůrce(i) Ananbeh, Hanadi (UZFG-Y) ORCID
Vodička, Petr (UZFG-Y) ORCID
Kupcová Skalníková, Helena (UZFG-Y) RID, ORCIDČíslo článku 4085 Zdroj.dok. International Journal of Molecular Sciences. - : MDPI
Roč. 22, č. 8 (2021)Poč.str. 16 s. Forma vydání Online - E Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova extracellular vesicle ; exosome ; neurodegeneration ; Huntington´s disease ; huntingtin Vědní obor RIV EB - Genetika a molekulární biologie Obor OECD Biochemical research methods CEP GA19-01747S GA ČR - Grantová agentura ČR LTC18079 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy Způsob publikování Open access Institucionální podpora UZFG-Y - RVO:67985904 UT WOS 000644326300001 EID SCOPUS 85104103614 DOI 10.3390/ijms22084085 Anotace Huntington's disease (HD) is a rare hereditary autosomal dominant neurodegenerative disorder, which is caused by expression of mutant huntingtin protein (mHTT) with an abnormal number of glutamine repeats in its N terminus, and characterized by intracellular mHTT aggregates (inclusions) in the brain. Exosomes are small extracellular vesicles that are secreted generally by all cell types and can be isolated from almost all body fluids such as blood, urine, saliva, and cerebrospinal fluid. Exosomes may participate in the spreading of toxic misfolded proteins across the central nervous system in neurodegenerative diseases. In HD, such propagation of mHTT was observed both in vitro and in vivo. On the other hand, exosomes might carry molecules with neuroprotective effects. In addition, due to their capability to cross blood-brain barrier, exosomes hold great potential as sources of biomarkers available from periphery or carriers of therapeutics into the central nervous system. In this review, we discuss the emerging roles of exosomes in HD pathogenesis, diagnosis, and therapy. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2022 Elektronická adresa https://www.mdpi.com/1422-0067/22/8/4085
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