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Cyclotriphosphazene-based star copolymers as structurally tunable nanocarriers with programmable biodegradability
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SYSNO ASEP 0541739 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Cyclotriphosphazene-based star copolymers as structurally tunable nanocarriers with programmable biodegradability Tvůrce(i) Androvič, Ladislav (UMCH-V) ORCID
Woldřichová, Lucie (UMCH-V) ORCID
Jozefjaková, Klaudia (UMCH-V)
Pechar, Michal (UMCH-V) RID, ORCID
Lynn, G. M. (US)
Kaňková, Dana (UMCH-V)
Malinová, L. (CZ)
Laga, Richard (UMCH-V) RID, ORCIDZdroj.dok. Macromolecules. - : American Chemical Society - ISSN 0024-9297
Roč. 54, č. 7 (2021), s. 3139-3157Poč.str. 19 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova cyclotriphosphazene derivatives ; hydrophilic polymers ; biodegradable nanoparticle carriers Vědní obor RIV CD - Makromolekulární chemie Obor OECD Polymer science CEP LTAUSA18173 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA19-08176S GA ČR - Grantová agentura ČR Způsob publikování Omezený přístup Institucionální podpora UMCH-V - RVO:61389013 UT WOS 000640891600013 EID SCOPUS 85104977140 DOI 10.1021/acs.macromol.0c02889 Anotace Myriad nanocarriers have been developed to improve the therapeutic index of low-molecular-weight drugs for cancer treatment, but many have suboptimal size and/or are too stable for optimal penetration into tumors and their subsequent excretion from the body. To address this challenge, we developed a series of novel nanocarriers based on star polymers consisting of hydrophilic poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) or poly(ethylene glycol) (PEG) polymer arms attached to hexavalent cyclotriphosphazene (CTP)-derived cores through either stable or stimuli-responsive linkers. The star polymers were assembled using either “grafting from” or “grafting onto” approaches and characterized by quantitative arm substitution at the core. The resulting star polymers were precisely defined water-soluble nanomaterials with a suitable hydrodynamic size (∼10–25 nm) for tumor uptake, those with stimuli-responsive linkers exhibited programmable pH- or cathepsin-mediated degradability. Finally, low-molecular-weight drugs—an anthracycline-based cancerostatic and an imidazoquinoline-based immunostimulant—were linked to exemplary CTP-based star polymers to demonstrate their suitability for drug delivery. Pracoviště Ústav makromolekulární chemie Kontakt Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Rok sběru 2022 Elektronická adresa https://pubs.acs.org/doi/10.1021/acs.macromol.0c02889
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