Počet záznamů: 1
Early infection-induced natural antibody response
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SYSNO ASEP 0541608 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Early infection-induced natural antibody response Tvůrce(i) Kubelková, K. (CZ)
Hudcovic, Tomáš (MBU-M) RID, ORCID
Kozáková, Hana (MBU-M) RID, ORCID
Pejchal, J. (CZ)
Macela, A. (CZ)Číslo článku 1541 Zdroj.dok. Scientific Reports. - : Nature Publishing Group - ISSN 2045-2322
Roč. 11, č. 1 (2021)Poč.str. 15 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova live vaccine strain ; bacterium francisella-tularensis ; early protective immunity ; intracellular bacterium ; t-cells Obor OECD Infectious Diseases CEP GA19-08294S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora MBU-M - RVO:61388971 UT WOS 000609782400062 EID SCOPUS 85100078976 DOI 10.1038/s41598-021-81083-0 Anotace There remains to this day a great gap in understanding as to the role of B cells and their products-antibodies and cytokines-in mediating the protective response to Francisella tularensis, a Gram-negative coccobacillus belonging to the group of facultative intracellular bacterial pathogens. We previously have demonstrated that Francisella interacts directly with peritoneal B-1a cells. Here, we demonstrate that, as early as 12 h postinfection, germ-free mice infected with Francisella tularensis produce infection-induced antibody clones reacting with Francisella tularensis proteins having orthologs or analogs in eukaryotic cells. Production of some individual clones was limited in time and was influenced by virulence of the Francisella strain used. The phylogenetically stabilized defense mechanism can utilize these early infection-induced antibodies both to recognize components of the invading pathogens and to eliminate molecular residues of infection-damaged self cells. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2022 Elektronická adresa https://www.nature.com/articles/s41598-021-81083-0
Počet záznamů: 1