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Opioid Receptor Regulation of Neuronal Voltage-Gated Calcium Channels
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SYSNO ASEP 0540957 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Opioid Receptor Regulation of Neuronal Voltage-Gated Calcium Channels Tvůrce(i) Weiss, Norbert (UOCHB-X) ORCID, RID
Zamponi, G. W. (CA)Zdroj.dok. Cellular and Molecular Neurobiology. - : Springer - ISSN 0272-4340
Roč. 41, č. 5 (2021), s. 839-847Poč.str. 9 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova G-protein coupled receptors ; voltage-gated calcium channels ; mu opioid receptor ; nociception opioid receptor Obor OECD Biochemistry and molecular biology Způsob publikování Omezený přístup Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000539386700001 EID SCOPUS 85086018753 DOI 10.1007/s10571-020-00894-3 Anotace Neuronal voltage-gated calcium channels play a pivotal role in the conversion of electrical signals into calcium entry into nerve endings that is required for the release of neurotransmitters. They are under the control of a number of cellular signaling pathways that serve to fine tune synaptic activities, including G-protein coupled receptors (GPCRs) and the opioid system. Besides modulating channel activity via activation of second messengers, GPCRs also physically associate with calcium channels to regulate their function and expression at the plasma membrane. In this mini review, we discuss the mechanisms by which calcium channels are regulated by classical opioid and nociceptin receptors. We highlight the importance of this regulation in the control of neuronal functions and their implication in the development of disease conditions. Finally, we present recent literature concerning the use of novel μ-opioid receptor/nociceptin receptor modulators and discuss their use as potential drug candidates for the treatment of pain. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Rok sběru 2022 Elektronická adresa https://doi.org/10.1007/s10571-020-00894-3
Počet záznamů: 1